Risk factors and outcomes of Clostridioides difficile infection in patients with colorectal cancer: critical perspective in management.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2025-06-14 DOI:10.1186/s13099-025-00717-0

Hamideh Raeisi, Spigaglia Patrizia, Amir Sadeghi, Fabrizio Barbanti, Glenn Tillotson, Hossein Safarpour, Mohamadreza Zali, Ehsan Nazemalhosseini Mojarad

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Abstract

Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide, causing a serious threat to global health and social burden. Clostridioides difficile infection (CDI) is one of the most important nosocomial infections and has a higher incidence in cancerous population compared with non-cancerous cases. Different risk factors, including gut microbiota dysbiosis, extensive surgery, chemotherapy, prolonged hospitalization, and antimicrobial therapy, compromise host defenses against CDI and contribute to cancer patients' susceptibility to this infection. The emergence of CDI in patients with CRC creates conditions for therapy escalation and prolonged hospitalization, highlighting the need for correct and effective CDI management in these patients. Here, common risk factors associated with CDI in patients with CRC are discussed. In addition, different available techniques for the prevention, detection, and treatment of CDI with the lowest impact on gut microbiota diversity are summarized. This review aims to improve the understanding of the interplay between CDI and CRC and provide new insights into restoring and maintaining gut microbiota balance during CDI management in patients with CRC.

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结直肠癌患者艰难梭菌感染的危险因素和结局：关键的管理观点。

结直肠癌（CRC）是全球第三大流行癌症，对全球健康造成严重威胁和社会负担。艰难梭菌感染（clostridiides difficile infection， CDI）是最重要的医院感染之一，在癌变人群中发病率高于非癌变人群。不同的危险因素，包括肠道菌群失调、广泛的手术、化疗、长期住院和抗菌治疗，会损害宿主对CDI的防御，并导致癌症患者对这种感染的易感性。结直肠癌患者CDI的出现为治疗升级和延长住院时间创造了条件，强调了对这些患者进行正确有效的CDI管理的必要性。本文讨论了与结直肠癌患者CDI相关的常见危险因素。此外，本文还总结了对肠道菌群多样性影响最小的CDI的预防、检测和治疗方法。本综述旨在提高对CDI和结直肠癌之间相互作用的理解，并为在结直肠癌患者CDI治疗期间恢复和维持肠道微生物群平衡提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).