Prognostic value of atherogenic index of plasma on the all-cause and causes-specific mortality among patients with metabolic dysfunction-associated steatotic liver disease.

IF 3.9 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Guo Song, Heyu Chu, Yuting Liu, Xiaoli Liu, Rong Gu
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Abstract

Background: The atherogenic index of plasma (AIP) has been proposed as a potential predictor of prognosis for atherosclerosis and cardiovascular disease (CVD). However, its prognostic value in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.

Methods: This study included 4,062 participants with MASLD from the Third National Health and Nutrition Examination Survey (NHANES III). Kaplan-Meier curves, the Cox proportional hazards regression model, and restricted cubic splines (RCS) were used to assess the associations between the AIP and both all-cause and cause-specific mortality in patients with MASLD. Additionally, subgroup analyses and interaction test were conducted.

Results: During a median follow-up of 311 months, a total of 1821 (44.83%) all-cause deaths, 606 (14.92%) CVD deaths and 313 (7.71%) diabetes deaths occurred. After adjusting for potential confounding factors, the hazard ratios (HR) for the highest tertile (AIP ≥ 0.30) compared to the lowest tertile (AIP < 0.01) were 1.41 (95% confidence interval [CI]: 1.17-1.68; P < 0.001) for all-cause mortality, 1.49 (95% CI: 1.07-2.09; P = 0.019) for CVD mortality, and 2.27 (95% CI: 1.28-4.01; P = 0.005) for diabetes mortality. Furthermore, subgroup analyses revealed that the highest tertile of AIP was associated with an increased risk of CVD mortality in MASLD patients with diabetes (HR = 2.46; 95% CI: 1.46-4.13; P < 0.001) or obesity/overweight (HR = 2.36; 95% CI: 1.41-3.95; P = 0.001).

Conclusions: The elevated AIP is independently associated with all-cause mortality, as well as CVD and diabetes mortality in patients with MASLD. AIP can be used as a prognostic indicator for patients with MASLD.

血浆动脉粥样硬化指数对代谢功能障碍相关脂肪变性肝病患者全因死亡率和病因特异性死亡率的预后价值
背景:血浆动脉粥样硬化指数(AIP)已被认为是动脉粥样硬化和心血管疾病(CVD)预后的潜在预测因子。然而,其在代谢功能障碍相关脂肪变性肝病(MASLD)患者中的预后价值尚不清楚。方法:本研究纳入了来自第三次全国健康与营养调查(NHANES III)的4062名MASLD患者。Kaplan-Meier曲线、Cox比例风险回归模型和限制性三次样条(RCS)被用于评估AIP与MASLD患者全因死亡率和病因特异性死亡率之间的关系。并进行亚组分析和交互作用检验。结果:在中位随访311个月期间,共发生全因死亡1821例(44.83%),心血管疾病死亡606例(14.92%),糖尿病死亡313例(7.71%)。在调整了潜在的混杂因素后,最高分位数(AIP≥0.30)与最低分位数(AIP)的危险比(HR)。结论:AIP升高与MASLD患者的全因死亡率、CVD和糖尿病死亡率独立相关。AIP可作为MASLD患者的预后指标。
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来源期刊
Diabetology & Metabolic Syndrome
Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
6.20
自引率
0.00%
发文量
170
审稿时长
7.5 months
期刊介绍: Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.
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