Association of inflammatory biomarkers with morbidity and mortality risk in patients with peripheral artery disease: a systematic review and -meta-analysis.

IF 5.5 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Mariana Fragão-Marques, Maria Francisca-Marques, João Rocha Neves, Tomris Ozben
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引用次数: 0

Abstract

Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis, which might progress due to inflammation. This systematic review assessed the association of specific inflammatory biomarkers with morbidity and mortality in PAD patients. MEDLINE and EMBASE databases were systematically searched for studies assessing evidence between inflammatory biomarkers and morbidity and mortality risks in PAD patients. Results were reported as Hazard Ratios (HR), Odds Ratios (OR), or mean and standard deviation. Effect estimates for high-sensitivity C-reactive protein (hs-CRP) were pooled using a random-effects model and respectively displayed in forest plots. The study reviewed a total of 7024 records, out of which 26 studies were included for qualitative synthesis and nine for quantitative synthesis. A total of 4673 patients were analyzed in the meta-analysis. Elevated baseline IL-6 levels were consistently linked to poor outcomes, including loss of patency and composite endpoints, such as major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Tumor necrosis factor-α (TNF-α) and related biomarkers were associated with adverse outcomes like mortality and patency loss. Elevated IL-1 levels predicted worse cardiovascular outcomes and IL-1 receptor antagonist levels indicated recurrence or new lesions post-surgery. Hs-CRP was statistically significantly associated with all-cause mortality and MALE in the pooled analysis. The study highlights the ability of inflammatory biomarkers to predict clinical outcomes in PAD patients. The strength of these associations varies based on the specific biomarker and clinical context.

外周动脉疾病患者炎症生物标志物与发病率和死亡率风险的关联:一项系统综述和荟萃分析
外周动脉疾病(PAD)是全身性动脉粥样硬化的一种表现,它可能因炎症而进展。本系统综述评估了特定炎症生物标志物与PAD患者发病率和死亡率的关系。系统地检索MEDLINE和EMBASE数据库,以评估炎症生物标志物与PAD患者发病率和死亡率风险之间的证据。结果以风险比(HR)、优势比(OR)或平均值和标准差报告。使用随机效应模型汇总了高敏感性c -反应蛋白(hs-CRP)的效应估计,并分别在森林样地中显示。本研究共回顾了7024篇文献,其中定性综合文献26篇,定量综合文献9篇。荟萃分析共分析了4673例患者。基线IL-6水平升高始终与不良结局相关,包括通畅丧失和复合终点,如主要不良心血管事件(MACE)和主要不良肢体事件(MALE)。肿瘤坏死因子-α (TNF-α)和相关生物标志物与死亡率和通畅丧失等不良结局相关。升高的IL-1水平预示着更糟糕的心血管预后,IL-1受体拮抗剂水平预示着术后复发或新的病变。在合并分析中,Hs-CRP与全因死亡率和男性有统计学显著相关。该研究强调了炎症生物标志物预测PAD患者临床结果的能力。这些关联的强度根据特定的生物标志物和临床环境而变化。
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来源期刊
CiteScore
20.00
自引率
0.00%
发文量
25
审稿时长
>12 weeks
期刊介绍: Critical Reviews in Clinical Laboratory Sciences publishes comprehensive and high quality review articles in all areas of clinical laboratory science, including clinical biochemistry, hematology, microbiology, pathology, transfusion medicine, genetics, immunology and molecular diagnostics. The reviews critically evaluate the status of current issues in the selected areas, with a focus on clinical laboratory diagnostics and latest advances. The adjective “critical” implies a balanced synthesis of results and conclusions that are frequently contradictory and controversial.
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