Isolation and Characterization of Seneca Valley Virus From Pig Transboundary Spread to the Mink Infection

IF 3.5 2区农林科学 Q2 INFECTIOUS DISEASES

Transboundary and Emerging Diseases Pub Date : 2025-06-16 DOI:10.1155/tbed/4428550

Ziliang Qin, Xinmiao He, Chao Chen, Shaojun Chen, Zida Nai, Yao Wang, Wentao Wang, Gang Li, Fang Wang, Ming Tian, Haijuan He, Heshu Chen, Di Liu, Xinpeng Jiang

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Abstract

Seneca Valley virus (SVV) infection has recently disseminated across pig farms in Canada, America, and China. The SVV has been identified in humans, rodents, and houseflies. Although cross-species transmission events may lead to limited subsequent transmission, sustained outbreaks have been observed in new mammalian hosts. Thus, in our study, we utilized molecular characteristics, pathological examination, and the immune response to ascertain whether mink could serve as a novel mammalian host for SVV. Here, our study utilized a porcine strain of SVV to infect minks orally, resulting in pathological changes in the intestines. In addition, SVV could stimulate a specific neutralizing antibody response. The neutralizing antibody against SVV has also been found in mink through an epidemiological investigation in Heilongjiang Province. This study highlights the role of SVV infection in minks as an impetus for viral evolution, which poses potential threats to livestock, public health, and economic prosperity.

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猪跨界传播到水貂的塞内卡谷病毒的分离与鉴定

塞内卡谷病毒（SVV）感染最近在加拿大、美国和中国的养猪场传播。已经在人类、啮齿动物和家蝇中发现了SVV。虽然跨物种传播事件可能导致有限的后续传播，但在新的哺乳动物宿主中观察到持续暴发。因此，在我们的研究中，我们利用分子特征、病理检查和免疫反应来确定水貂是否可以作为SVV的新型哺乳动物宿主。在这里，我们的研究利用猪SVV菌株口服感染水貂，导致肠道病理改变。此外，SVV可以刺激特异性中和抗体反应。通过流行病学调查，在黑龙江省水貂中也发现了SVV的中和抗体。该研究强调了水貂中SVV感染作为病毒进化动力的作用，这对牲畜、公众健康和经济繁荣构成潜在威胁。

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来源期刊

Transboundary and Emerging Diseases 农林科学-传染病学

CiteScore

8.90

自引率

9.30%

发文量

350

审稿时长

1 months

期刊介绍： Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions): Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread. Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope. Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies. Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies). Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.