Tactics to Improve the Photodynamic Therapeutic Efficacy Based on Nanomaterials

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-04-19 DOI:10.1002/cjoc.202401177

Yinghao Cao, Xiaoping Qian, Mengqi Shi, Xiang Sun, Jianhua Zou, Xiaoyuan Chen

{"title":"Tactics to Improve the Photodynamic Therapeutic Efficacy Based on Nanomaterials","authors":"Yinghao Cao, Xiaoping Qian, Mengqi Shi, Xiang Sun, Jianhua Zou, Xiaoyuan Chen","doi":"10.1002/cjoc.202401177","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>The development of photodynamic therapy (PDT), from its initial discovery of photodynamic effects to its current use in various medical conditions, is a testament to its therapeutic potential. Recent breakthroughs in nanotechnology have significantly enhanced the effectiveness of PDT. Typical nanomaterials (NMs), including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and nanozymes have been introduced to enhance the photodynamic efficacy because they can enhance the delivery of PSs, and effectively overcome insufficient targeting specificity, limited tissue penetration depth, and hypoxic microenvironments, thereby amplifying its therapeutic efficacy. However, the clinical application of these NMs in PDT faces several challenges, including concerns regarding biocompatibility, long-term biosafety, and economic feasibility. To further advance PDT, researchers should focus on designing NMs to improve therapeutic outcomes, exploring combination therapies with PDT, and conducting translational clinical trials to validate the safety and therapeutic efficacy of these novel PDT approaches. This review summarizes the recent progress in PDT based on NMs, especially MOFs, COFs and nanozymes and their application in disease treatment. We aim to provide guidance for future research and clinical practice in advancing NMs-enhanced PDT, paving the way for more effective therapeutic strategies.</p>\n \n <p></p>\n </section>\n \n <section>\n \n <h3> Key Scientists</h3>\n \n <p></p>\n </section>\n </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 14","pages":"1731-1755"},"PeriodicalIF":5.5000,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202401177","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

The development of photodynamic therapy (PDT), from its initial discovery of photodynamic effects to its current use in various medical conditions, is a testament to its therapeutic potential. Recent breakthroughs in nanotechnology have significantly enhanced the effectiveness of PDT. Typical nanomaterials (NMs), including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and nanozymes have been introduced to enhance the photodynamic efficacy because they can enhance the delivery of PSs, and effectively overcome insufficient targeting specificity, limited tissue penetration depth, and hypoxic microenvironments, thereby amplifying its therapeutic efficacy. However, the clinical application of these NMs in PDT faces several challenges, including concerns regarding biocompatibility, long-term biosafety, and economic feasibility. To further advance PDT, researchers should focus on designing NMs to improve therapeutic outcomes, exploring combination therapies with PDT, and conducting translational clinical trials to validate the safety and therapeutic efficacy of these novel PDT approaches. This review summarizes the recent progress in PDT based on NMs, especially MOFs, COFs and nanozymes and their application in disease treatment. We aim to provide guidance for future research and clinical practice in advancing NMs-enhanced PDT, paving the way for more effective therapeutic strategies.

Key Scientists

Abstract Image

查看原文本刊更多论文

基于纳米材料提高光动力治疗效果的策略

光动力疗法（PDT）的发展，从最初发现光动力效应到目前在各种医疗条件下的应用，证明了它的治疗潜力。纳米技术的最新突破大大提高了PDT的有效性。典型的纳米材料（NMs），包括金属有机框架（MOFs）、共价有机框架（COFs）和纳米酶，由于它们可以增强ps的递送，有效克服靶向特异性不足、组织穿透深度有限和缺氧微环境，从而增强其光动力功效，从而增强其治疗效果。然而，这些纳米材料在PDT中的临床应用面临着一些挑战，包括生物相容性、长期生物安全性和经济可行性。为了进一步推进PDT，研究人员应该专注于设计NMs以改善治疗效果，探索与PDT联合治疗，并进行转化临床试验以验证这些新型PDT方法的安全性和治疗效果。本文综述了近年来基于纳米颗粒的PDT研究进展，特别是mof、COFs和纳米酶及其在疾病治疗中的应用。我们的目标是为未来的研究和临床实践提供指导，以推进纳米粒子增强的PDT，为更有效的治疗策略铺平道路。关键的科学家

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.