Giulia Coffetti, Giorgio Facchetti, Alessandro Ajò, Isabella Rimoldi, Luisa De Cola
{"title":"Breakable Nanomaterials to Allow Hair Coloring with Natural Dyes","authors":"Giulia Coffetti, Giorgio Facchetti, Alessandro Ajò, Isabella Rimoldi, Luisa De Cola","doi":"10.1002/hlca.202500007","DOIUrl":null,"url":null,"abstract":"<p>The use of melanin as a colorant has been significantly limited by its low solubility and the difficulty of penetrating the hair shaft or follicles. However, the proposed nanotechnological approach demonstrates that it is possible to encapsulate a melanin precursor, 5,6-dihydroxyindole (DHI), within breakable particles and trigger its oxidation into insoluble black melanin, which can be released upon the degradation of the carrier using UV light. This process can be monitored via UV spectroscopy and has also been successfully tested on hair. In fact, when applied to human white hair, the result was a brownish coloration, with melanin naturally formed and adsorbed by the hair. This mild and harmless method shows great promise for the development of nanoparticles capable of penetrating hair follicles, potentially enabling natural hair pigmentation at the roots.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"108 6","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202500007","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helvetica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hlca.202500007","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The use of melanin as a colorant has been significantly limited by its low solubility and the difficulty of penetrating the hair shaft or follicles. However, the proposed nanotechnological approach demonstrates that it is possible to encapsulate a melanin precursor, 5,6-dihydroxyindole (DHI), within breakable particles and trigger its oxidation into insoluble black melanin, which can be released upon the degradation of the carrier using UV light. This process can be monitored via UV spectroscopy and has also been successfully tested on hair. In fact, when applied to human white hair, the result was a brownish coloration, with melanin naturally formed and adsorbed by the hair. This mild and harmless method shows great promise for the development of nanoparticles capable of penetrating hair follicles, potentially enabling natural hair pigmentation at the roots.
期刊介绍:
Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.