Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology

IF 4.6 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Huifen Ma , Zhiyang Yu , Qiong Qiao , Wenpan Wang , Zhonghua Li , Pan Wang , Junying Song , Xiaowei Zhang , Yunfang Su , Yiran Sun , Zhishen Xie , Zhenqiang Zhang
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Abstract

There has been increasing interest in the connection between AD, gut microbiota, and metabolites. Kai-Xin-San (KXS) has been commonly employed in ancient and modern Chinese clinical trials for the treatment of dementia; however, whether the protective effect of KXS in AD is related to the gut microbiota remains elusive. APP/PS1 mice were used as the model of AD. 43 key metabolites influenced by KXS were screened using untargeted metabolomics. At the genus level, Clostridium_IV, Eubacterium, Acetatifactor, etc., were identified to be impacted by KXS using 16S rRNA sequencing. Additionally, we identified 9 distinct intestinal floras at the genus level that were correlated with 13 pivotal differential metabolites related to cognitive impairment. KXS also inhibited the neuroinflammation, mostly via regulating the key metabolites. A potential relationship between gut microbiota, metabolites, and neuroinflammation is suggested as a protective mechanism of KXS in AD. These findings provide support for further development of KXS.

Abstract Image

代谢组学和微生物学见解:开心散对阿尔茨海默病病理的影响
人们对阿尔茨海默病、肠道微生物群和代谢物之间的联系越来越感兴趣。开心散(KXS)在中国古今临床试验中常用,用于治疗痴呆;然而,KXS对AD的保护作用是否与肠道菌群有关尚不清楚。以APP/PS1小鼠为AD模型。利用非靶向代谢组学方法筛选了43种受KXS影响的关键代谢物。在属水平上,通过16S rRNA测序,鉴定出Clostridium_IV、Eubacterium、Acetatifactor等受KXS影响。此外,我们在属水平上鉴定了9种不同的肠道菌群,这些菌群与13种与认知障碍相关的关键差异代谢物相关。KXS对神经炎症也有抑制作用,主要通过调节关键代谢物。肠道菌群、代谢物和神经炎症之间的潜在关系被认为是KXS在AD中的保护机制。这些发现为KXS的进一步发展提供了支持。
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来源期刊
iScience
iScience Multidisciplinary-Multidisciplinary
CiteScore
7.20
自引率
1.70%
发文量
1972
审稿时长
6 weeks
期刊介绍: Science has many big remaining questions. To address them, we will need to work collaboratively and across disciplines. The goal of iScience is to help fuel that type of interdisciplinary thinking. iScience is a new open-access journal from Cell Press that provides a platform for original research in the life, physical, and earth sciences. The primary criterion for publication in iScience is a significant contribution to a relevant field combined with robust results and underlying methodology. The advances appearing in iScience include both fundamental and applied investigations across this interdisciplinary range of topic areas. To support transparency in scientific investigation, we are happy to consider replication studies and papers that describe negative results. We know you want your work to be published quickly and to be widely visible within your community and beyond. With the strong international reputation of Cell Press behind it, publication in iScience will help your work garner the attention and recognition it merits. Like all Cell Press journals, iScience prioritizes rapid publication. Our editorial team pays special attention to high-quality author service and to efficient, clear-cut decisions based on the information available within the manuscript. iScience taps into the expertise across Cell Press journals and selected partners to inform our editorial decisions and help publish your science in a timely and seamless way.
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