Cobalt-catalyzed C-H perfluoroalkylation of anilines

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2025-06-16 DOI:10.1016/j.jfluchem.2025.110437

Shota Mizuno , Yoichi Obitsu , Munenori Inoue

引用次数: 0

Abstract

Cobalt-catalyzed perfluoroalkylation of anilines under mild conditions was developed. The combination of Co(acac)₂/dppe/Zn efficiently catalyzed perfluoroalkylation of aniline derivatives with perfluoroalkyl iodides to give the corresponding target products in good to moderate yields. A detailed reaction mechanism was proposed, and it was found that the yields are substrate-dependent because the reaction proceeds by a radical addition-like reaction.

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钴催化苯胺的C-H全氟烷基化

研究了在温和条件下钴催化苯胺的全氟烷基化反应。Co(acac)2/dppe/Zn的组合有效地催化了苯胺衍生物与全氟烷基碘化物的全氟烷基化反应，得到了产率良好至中等的相应目标产物。提出了详细的反应机理，发现产率与底物有关，因为反应是通过类似自由基加成的反应进行的。

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.