The role of the Nrf2 pathway in inhibiting ferroptosis in kidney disease and its future prospects

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-06-13 DOI:10.1016/j.prp.2025.156084

Jia-Yuan Huang, Hai-ning Yu

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Abstract

Kidney disease (KD) has gradually become a major social and economic burden on the healthcare system. Recent studies highlight ferroptosis as a critical mechanism in the progression of these conditions. Recognized for its essential role in renal pathogenesis, ferroptosis is attracting increasing research attention and emerging as a key focus of investigation. The Nrf2 signaling pathway, known for its regulatory influence on ferroptosis, plays a central role in this context. Activation of the nuclear factor E2-related factor 2 (Nrf2) pathway and the subsequent attenuation of ferroptosis present substantial opportunities as novel therapeutic targets for managing kidney injury (KI). This article summarizes the latest mechanism of action of the Nrf2 pathway in ferroptosis, explores how the Nrf2 pathway affects ferroptosis in KD therapy, and investigates the potential therapeutic effects of natural products targeting the Nrf2 pathway. These natural products have been shown to inhibit ferroptosis through the Nrf2 pathway, providing new insights and therapeutic strategies for the clinical and individualized management of KD.

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Nrf2通路在肾脏疾病中抑制铁下垂的作用及其未来前景

肾脏疾病（KD）已逐渐成为医疗保健系统的主要社会和经济负担。最近的研究强调铁下垂是这些疾病进展的关键机制。由于其在肾脏发病中的重要作用，上睑下垂引起了越来越多的研究关注，并成为研究的重点。Nrf2信号通路以其对铁下垂的调节作用而闻名，在此背景下起着核心作用。核因子e2相关因子2 （Nrf2）途径的激活和随后铁下垂的衰减为管理肾损伤（KI）提供了大量的新治疗靶点。本文综述了Nrf2通路在铁下垂中的最新作用机制，探讨了Nrf2通路在KD治疗中对铁下垂的影响，并探讨了靶向Nrf2通路的天然产物的潜在治疗效果。这些天然产物已被证明通过Nrf2途径抑制铁下垂，为KD的临床和个体化治疗提供了新的见解和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.