The shift toward nanovaccination: A comprehensive review of advancing nanovaccination for combinatory immune regulation therapies to treat infectious diseases and cancer

IF 4.7 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2025-06-16 DOI:10.1016/j.intimp.2025.115090

Khadija Raziq, Ting Xue, Dongdong Sun

{"title":"The shift toward nanovaccination: A comprehensive review of advancing nanovaccination for combinatory immune regulation therapies to treat infectious diseases and cancer","authors":"Khadija Raziq, Ting Xue, Dongdong Sun","doi":"10.1016/j.intimp.2025.115090","DOIUrl":null,"url":null,"abstract":"<div><div>Vaccination is an essential tool in combating infectious disease and holds significant potential in cancer immunotherapy. Recent advances in nanotechnology have paved the way for nanovaccines development, which leverage nanoparticles to enhance vaccines delivery, stability, and immunogenicity. This review article examines the composition of nanovaccines, detailing the characteristics properties of antigens and adjuvant along with the various nanomaterial commonly employed, including liposomes, polymeric nanoparticles, biomimetic structures, as well as organic and inorganic nanocarriers. The mechanism of action of nanovaccines are discussed which contribute to robust immune activation via initiating cellular and humoral mediated responses. Special attention is given to the innovative application of nanovaccines in combinatory immunotherapy, including photo, sonodynamic, magnetic hyperthermia and chemodynamic therapies. These multifunctional platforms enable localized treatment, promote antigen release, and boost immune responses, offering promising strategies for effective infectious disease and cancer immunotherapy. Furthermore, by highlighting the “nano advantages,” this review underscores the transformative potential of nanovaccines to elevate immune responses beyond the capabilities of traditional vaccines. Lastly, the challenges of nanovaccine formulation are discussed with significant implication for future immunization and therapeutic strategies.</div></div>","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":"161 ","pages":"Article 115090"},"PeriodicalIF":4.7000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International immunopharmacology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156757692501080X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Vaccination is an essential tool in combating infectious disease and holds significant potential in cancer immunotherapy. Recent advances in nanotechnology have paved the way for nanovaccines development, which leverage nanoparticles to enhance vaccines delivery, stability, and immunogenicity. This review article examines the composition of nanovaccines, detailing the characteristics properties of antigens and adjuvant along with the various nanomaterial commonly employed, including liposomes, polymeric nanoparticles, biomimetic structures, as well as organic and inorganic nanocarriers. The mechanism of action of nanovaccines are discussed which contribute to robust immune activation via initiating cellular and humoral mediated responses. Special attention is given to the innovative application of nanovaccines in combinatory immunotherapy, including photo, sonodynamic, magnetic hyperthermia and chemodynamic therapies. These multifunctional platforms enable localized treatment, promote antigen release, and boost immune responses, offering promising strategies for effective infectious disease and cancer immunotherapy. Furthermore, by highlighting the “nano advantages,” this review underscores the transformative potential of nanovaccines to elevate immune responses beyond the capabilities of traditional vaccines. Lastly, the challenges of nanovaccine formulation are discussed with significant implication for future immunization and therapeutic strategies.

Abstract Image

查看原文本刊更多论文

向纳米疫苗的转变：对推进纳米疫苗用于联合免疫调节疗法治疗传染病和癌症的全面回顾

疫苗接种是对抗传染病的重要工具，在癌症免疫治疗中具有重大潜力。纳米技术的最新进展为纳米疫苗的开发铺平了道路，纳米疫苗利用纳米颗粒来增强疫苗的递送、稳定性和免疫原性。本文综述了纳米疫苗的组成，详细介绍了抗原和佐剂的特性以及常用的各种纳米材料，包括脂质体、聚合纳米颗粒、仿生结构以及有机和无机纳米载体。本文讨论了纳米疫苗的作用机制，纳米疫苗通过启动细胞和体液介导的反应来促进强大的免疫激活。特别关注纳米疫苗在组合免疫疗法中的创新应用，包括光、声动力、磁热疗和化学动力疗法。这些多功能平台能够实现局部治疗，促进抗原释放，增强免疫反应，为有效的传染病和癌症免疫治疗提供了有希望的策略。此外，通过强调“纳米优势”，这篇综述强调了纳米疫苗在提高免疫反应方面的变革性潜力，超越了传统疫苗的能力。最后，讨论了纳米疫苗配方的挑战，对未来的免疫和治疗策略具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.