Efficacy, food safety and microbial modulation of prothioconazole in the control of peanut pod rot

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2025-06-13 DOI:10.1002/ps.8973

Kaidi Cui, Sirui Shen, Bowei Han, Song Yang, Qinqin Wang, Xuewei Mao, Guoyan Zhang, Leiming He, Lin Zhou

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引用次数: 0

Abstract

BACKGROUND

Peanut, a globally cultivated oilseed crop of significant economic value, faces substantial yield losses due to pod rot disease caused by Fusarium solani. We preliminarily found that prothioconazole had great inhibition activity against F. solani. This study aims to further comprehensively evaluate the application potential of prothioconazole for the control of peanut pod rot from in vitro sensitivity, efficacy, food safety and microbial modulation.

RESULTS

Prothioconazole exhibited great antifungal activity against the mycelial growth of F. solani by inhibiting the biosynthesis of ergosterol. The mean EC₅₀ value of prothioconazole against 132 F. solani isolates was 1.35 ± 0.11 mg L⁻¹. The protective efficacy of prothioconazole was higher than curative efficacy on detached peanut pods. Seed dressing with prothioconazole showed great antifungal activity against F. solani and was relatively safe on the germination and emergence of peanuts. However, prothioconazole applied by seed dressing was ineffective in the field. In comparison, spraying of prothioconazole at 720 g a.i./ha on the soil surface around peanut plants three times every 14 days from pegging until full seed could effectively control peanut pod rot (efficacy of 77.04% and 87.49% in 2023 and 2024, respectively) and increased the peanut yield (by 28.03% and 37.21% in 2023 and 2024, respectively). At harvest, the terminal residues of prothioconazole and its metabolite prothioconazole-desthio in soil, shells and kernels of peanuts were below the maximum residue limit (MRL, 0.02 mg/kg), suggesting a low risk to the environment and humans. At the same time, prothioconazole increased the abundance of bacteria and actinomycetes and decreased the number of fungi.

CONCLUSION

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原硫康唑防治花生豆荚腐病的疗效、食品安全性及微生物调控

花生是一种全球种植的具有重要经济价值的油料作物，由于枯萎病引起的豆荚腐病，花生面临着巨大的产量损失。初步发现，原硫康唑对真菌有较强的抑制作用。本研究旨在从体外敏感性、药效、食品安全性和微生物调控等方面进一步综合评价原硫康唑防治花生豆腐病的应用潜力。结果原硫代康唑通过抑制麦角甾醇的生物合成，对茄枯菌菌丝生长表现出较强的抑制作用。原硫康唑对132株梭菌的平均EC50值为1.35±0.11 mg L−1。原硫康唑对离体花生豆荚的保护作用高于疗效。用原硫康唑处理花生种子，对茄枯菌有较强的抑制作用，对花生的萌发和出苗相对安全。然而，原硫康唑在田间拌种效果不佳。在花生株周土壤表面每14 d喷施3次720 g a.i./ha的原硫康唑，可有效防治花生烂荚病（2023年和2024年的防治效果分别为77.04%和87.49%），提高花生产量（2023年和2024年分别为28.03%和37.21%）。收获时，原硫康唑及其代谢物原硫康唑-地硫磷在土壤、花生壳和花生仁中的末端残留量均低于最大残留限量（MRL, 0.02 mg/kg），对环境和人体的风险较低。同时，原硫康唑增加了细菌和放线菌的丰度，减少了真菌的数量。结论总体而言，原硫康唑具有较高的生物活性、有效性和安全性，在防治荚果枯萎病方面具有广阔的应用前景。©2025化学工业学会。

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.