{"title":"Chemical constituents of <i>Crepis napifera</i> (Franch.) Babc. and their anti-inflammatory activities.","authors":"Gen-Lin Yang, Zhi-Nan Mei","doi":"10.1080/14786419.2025.2513042","DOIUrl":null,"url":null,"abstract":"<p><p>A chemical study of <i>Crepis napifera</i> led to the isolation and identification of four compounds. Spectroscopic analysis revealed that these compounds belong to the class of eudesmane sesquiterpenes;guaiacane sesquiterpenes and their derivatives, including two novel compounds named Huanyangshen A (<b>1</b>) and Huanyangshen B (<b>2</b>). The absolute configurations of these new compounds were established through the comparison of experimental and calculated ECD spectra. Additionally, the anti-inflammatory properties of these compounds were assessed by evaluating their ability to inhibit LPS-induced NO production in RAW264.7 cells. The results indicated that the compound had potential inhibitory activity. Among them, the IC<sub>50</sub> value of compound 1 was 24.97 <i>μ</i>M, which was comparable to the IC<sub>50</sub> value of the positive control minocycline (31.54 <i>μ</i>M).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2513042","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
A chemical study of Crepis napifera led to the isolation and identification of four compounds. Spectroscopic analysis revealed that these compounds belong to the class of eudesmane sesquiterpenes;guaiacane sesquiterpenes and their derivatives, including two novel compounds named Huanyangshen A (1) and Huanyangshen B (2). The absolute configurations of these new compounds were established through the comparison of experimental and calculated ECD spectra. Additionally, the anti-inflammatory properties of these compounds were assessed by evaluating their ability to inhibit LPS-induced NO production in RAW264.7 cells. The results indicated that the compound had potential inhibitory activity. Among them, the IC50 value of compound 1 was 24.97 μM, which was comparable to the IC50 value of the positive control minocycline (31.54 μM).
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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