Bioactive Compounds and Biological Activities of Sarcomphalus joazeiro (Mart.) Hauenschild.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-06-13 DOI:10.1002/cbdv.202500700

Natália Kelly Gomes de Carvalho, Mariana Pereira da Silva, Débora Odília Duarte Leite, Fabiola Fernandes Galvão Rodrigues, José Galberto Martins da Costa

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引用次数: 0

Abstract

Sarcomphalus joazeiro (Mart.) Hauenschild (Rhamnaceae), commonly referred to as "juá" or "joazeiro," is a native and endemic species of the Brazilian semiarid region. This review aims to compile all information on the ethnobotanical, chemical, biological, and biotechnological aspects of the species, including data on patents. The methodology employed involved an integrative review of all published literature from 1984 to 2024. As a result, 25 articles and 18 patents were selected for this study. The species demonstrated antioxidant, antimicrobial, anxiolytic, and gastroprotective activities, among others. These bioactivities are attributed to the presence of saponins and flavonoids, main constituents of its bark and leaves, respectively. Pharmacokinetic studies suggest that nanoformulation systems can increase the solubility and absorption of these bioactive compounds. Notably, patented products derived from S. joazeiro are targeted at the food, cosmetic, and personal hygiene industries. Future research on this species is necessary to evaluate the toxicological profile, isolation of compounds, mechanisms of action, and bioavailability.

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麻麻的生物活性成分及生物活性研究Hauenschild。

Sarcomphalus joazeiro （Mart）Hauenschild（鼠李科），通常被称为“ju”或“joazeiro”，是巴西半干旱地区的本地和特有物种。本综述旨在汇编该物种的民族植物学、化学、生物学和生物技术方面的所有信息，包括专利数据。采用的方法包括对1984年至2024年所有已发表的文献进行综合审查。因此，本研究选择了25篇文章和18项专利。该物种表现出抗氧化、抗菌、抗焦虑和胃保护活性等。这些生物活性归因于其树皮和叶子的主要成分皂苷和类黄酮的存在。药代动力学研究表明，纳米制剂系统可以增加这些生物活性化合物的溶解度和吸收。值得注意的是，来自S. joazeiro的专利产品针对的是食品，化妆品和个人卫生行业。今后对其进行毒理学、化合物分离、作用机制和生物利用度等方面的研究是十分必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.