Maternal vitamin D regulates the metabolic rearrangement of offspring CD4⁺ T cells in response to intestinal inflammation.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-06-12 DOI:10.1016/j.celrep.2025.115857

Binjun Zhu, Jingwei Yang, Ruiling Fan, Haiyang Song, Lanlan Zhong, Tianli Zeng, Runmin Long, Xing Wan, Qingxi Li, Lei Liu, Jiang Xie

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Abstract

Children with autism spectrum disorders often have increased susceptibility to intestinal inflammation. However, the mechanisms and prevention of gastrointestinal immune dysfunction remain unclear. We demonstrate that maternal high vitamin D (VitD) level can rescue abnormal intestinal immune phenotypes in offspring that exhibit autism-like phenotypes due to exposure to maternal inflammation. Offspring exposed to dual insult of maternal inflammation and VitD deprivation show increased susceptibility to intestinal inflammation. Maternal high VitD level altered the metabolic patterns and chromatin accessibility of offspring CD4⁺ T cells and rescued the abnormal immune state of offspring induced by maternal immune activation (MIA). Additionally, MIA has long-term impacts on the immune phenotype of offspring in the second litter. Our findings suggest why exposure in utero to high inflammation and low maternal VitD levels increase the risk of inflammatory diseases in offspring.

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母体维生素D调节子代CD4+ T细胞在肠道炎症反应中的代谢重排。

患有自闭症谱系障碍的儿童对肠道炎症的易感性往往更高。然而，胃肠免疫功能障碍的机制和预防仍不清楚。我们证明，母体高维生素D （VitD）水平可以挽救由于暴露于母体炎症而表现出自闭症样表型的后代的异常肠道免疫表型。暴露于母体炎症和维生素d剥夺双重损伤的后代对肠道炎症的易感性增加。母体高维生素d水平改变了子代CD4+ T细胞的代谢模式和染色质可及性，挽救了母体免疫激活（MIA）诱导的子代异常免疫状态。此外，MIA对第二胎子代的免疫表型有长期影响。我们的研究结果表明，为什么在子宫内暴露于高炎症和低母体维生素d水平会增加后代患炎症性疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.