Predictors of Hypocalcemia Post Parathyroidectomy for Primary Hyperparathyroidism; a Single Center Study

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM
Khaled A. Obeidat, Nesreen A. Saadeh, Renad Msameh, Ajwad Obeidat, Omar Mar'ey, Ahmad Bakkar, Qutaiba Manasrah
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引用次数: 0

Abstract

Background

Hypocalcemia is a common event after parathyroidectomy for primary hyperparathyroidism (PHPT). This study aimed to explore the incidence of hypocalcemia, determine risk factors, and identify serum biomarkers associated with the development of this condition.

Methods

A retrospective study that included 116 patients with PHPT who underwent parathyroidectomy at a tertiary care facility in Jordan over 16 years (2006–2022) in this study. Patients were classified as having postoperative hypocalcemia if they developed serum calcium levels < 2.15 mmol/L within the first week following parathyroidectomy. Logistic regression analysis was performed to determine predictors of hypocalcemia. Spearman's rank correlation coefficient and ROC curves were used to assess relationships between variables as well as determine cutoffs for these predictors.

Results

Of the 116 patients studied, 57.7% developed hypocalcemia after parathyroidectomy. High preoperative alkaline phosphatase (ALP), low preoperative corrected calcium, high preoperative parathyroid (PTH), and younger age were shown to be significantly higher in patients who developed hypocalcemia after parathyroidectomy. Multivariate logistic regression showed a low preoperative corrected calcium level was an independent predictor of postoperative hypocalcemia (p = 0.036). A high level of preoperative alkaline phosphatase was also considered an independent predictor of hypocalcemia development (OR = 1.007, 95% CI: 1.002–1.012). Patients who had pre-operative ALP less than 208.5 U/L were unlikely to develop postoperative hypocalcemia.

Conclusion

Our study identified higher preoperative ALP, lower pre-operative corrected calcium, higher pre-operative PTH levels, and younger age as risk factors for postoperative hypocalcemia. Preoperative ALP and preoperative corrected calcium were shown to be independent predictors of hypocalcemia development.

Abstract Image

原发性甲状旁腺功能亢进患者甲状旁腺切除术后低钙的预测因素单中心研究
背景:低钙血症是原发性甲状旁腺功能亢进(PHPT)的甲状旁腺切除术后的常见事件。本研究旨在探讨低钙血症的发病率,确定危险因素,并确定与该疾病发展相关的血清生物标志物。方法一项回顾性研究包括116例PHPT患者,这些患者在约旦三级医疗机构接受了16年(2006-2022)的甲状旁腺切除术。如果患者在甲状旁腺切除术后第一周内血清钙水平达到2.15 mmol/L,则归为术后低钙血症。采用Logistic回归分析确定低钙血症的预测因素。Spearman等级相关系数和ROC曲线用于评估变量之间的关系以及确定这些预测因子的截止点。结果116例患者中,57.7%在甲状旁腺切除术后出现低钙。在甲状旁腺切除术后发生低钙血症的患者中,术前碱性磷酸酶(ALP)高、术前校正钙低、术前甲状旁腺(PTH)高、年龄更小的患者明显更高。多因素logistic回归显示术前校正钙水平低是术后低钙血症的独立预测因子(p = 0.036)。术前高水平碱性磷酸酶也被认为是低钙发展的独立预测因子(OR = 1.007, 95% CI: 1.002-1.012)。术前ALP低于208.5 U/L的患者不太可能发生术后低钙血症。结论:术前ALP升高、术前校正钙降低、术前甲状旁腺激素升高、年龄较小是术后低钙血症的危险因素。术前ALP和术前校正钙被证明是低钙发展的独立预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.00
自引率
0.00%
发文量
66
审稿时长
6 weeks
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