Radiation-induced degradation of sulfonamides (SAs) antibiotics by gamma radiation: Effect of ferrous ion

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-06-13 DOI:10.1016/j.radphyschem.2025.113076

Yuankun Liu , Yuening Song , Jianlong Wang

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Abstract

In this study, the radiation-induced degradation of two sulfonamides (SAs): sulfadiazine (SD) and sulfamethazine (SMT), was investigated, focusing on the synergistic effect of ferrous ion (Fe²⁺). The initial concentration of SD and SMT solutions were 20 mg/L, which were irradiated in the presence of 0.4 mM Fe²⁺. The results showed that gamma radiation was effective in SAs degradation and the degradation reaction conformed to the pseudo first-order kinetics. However, the removal of TOC (Total Organic Carbon) and TN (Total Nitrogen) were not as effective as that of SAs degradation. TOC removal efficiency was less than 10 % at 1.0 kGy, while 80 % of SD and 90 % of SMT were removed. Sulfate (SO₄²⁻) and two small molecules of organic acids were detected. The possible pathways of SD and SMT degradation were investigated by density functional theory (DFT) and the analysis of intermediate products. The biodegradability of SAs-containing solution could be enhanced obviously by gamma radiation. More importantly, the comprehensive toxicity of the final intermediates was lower than that of SAs, based on the quantitative structure-activity relationship (QSAR) prediction.

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γ辐射对磺胺类抗生素的降解作用：铁离子的影响

本研究研究了两种磺胺类化合物：磺胺嘧啶（SD）和磺胺乙嘧啶（SMT）的辐射降解，重点研究了亚铁离子（Fe2+）的协同作用。SD和SMT溶液初始浓度为20 mg/L，在0.4 mM Fe2+存在下辐照。结果表明，伽马辐射对砷的降解是有效的，降解反应符合准一级动力学。但TOC （Total Organic Carbon，总有机碳）和TN （Total Nitrogen，总氮）的去除效果不如sa的降解效果。在1.0 kGy下，TOC去除率低于10%，而SD去除率为80%，SMT去除率为90%。硫酸盐（SO42−）和两种小分子有机酸被检测到。利用密度泛函理论（DFT）和中间产物分析，探讨了SD和SMT降解的可能途径。伽马辐射能明显提高含sas溶液的生物降解性。更重要的是，根据定量构效关系（QSAR）预测，最终中间体的综合毒性低于SAs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.