Five new 14-oxygenated taxanes from the cell cultures of Taxus × media

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-06-11 DOI:10.1016/j.fitote.2025.106676

Yuxin Wang , Changkang Li , Songyang Sui, Jimei Liu, Jungui Dai

引用次数: 0

Abstract

Plant cell cultures of Taxus is a noteworthy resource of structurally novel taxanes. Here, five new 14‑oxygenated 6/8/6-type taxanes (1–5, mediataxanes DH) were isolated and their structures with absolute configurations were elucidated on the basis of comprehensive spectroscopic data and single-crystal X-ray diffraction analyses. The in vitro biological activity assays showed that mediataxane D (1) exhibited potent cytotoxicity against cervical carcinoma HeLa cells with an IC₅₀ value of 4.5 μM.

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从红豆杉×培养基细胞培养中获得5个新的14-氧合紫杉烷

红豆杉植物细胞培养物是结构新颖的红豆杉烷的重要来源。本文分离了5个新的14 -氧合的6/8/6型紫杉烷（1-5,mediataxanes DH），并通过综合光谱数据和单晶x射线衍射分析对它们的绝对构型进行了结构鉴定。体外生物活性实验表明，介质胞烷D(1)对宫颈癌HeLa细胞具有较强的细胞毒性，IC50值为4.5 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.