Advances in single-cell omics: Transformative applications in basic and clinical research

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-06-14 DOI:10.1016/j.ceb.2025.102548

Mohammed Inayatullah , Anuj Kumar Dwivedi , Vijay K. Tiwari

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引用次数: 0

Abstract

Recent advancements in single-cell RNA sequencing, spatial transcriptomics, and multi-omics integration have enabled researchers to dissect complex tissues and identify distinct cell populations with unique functional states. This review discusses the application of single-cell omics in diverse fields, including cancer research and developmental biology, showcasing how they reveal insights into cellular interactions, disease mechanisms, and therapeutic responses. Notable studies illustrate the potential of single-cell approaches to uncover novel biomarkers and therapeutic targets, particularly in heterogeneous diseases such as cancer and neurodevelopmental disorders. Furthermore, the review emphasizes the importance of integrating single-cell data with computational models to enhance our understanding of cellular dynamics and microenvironmental influences. Overall, this review underscores the critical role of single-cell omics in advancing our knowledge of biology and its applications in clinical settings, paving the way for personalized medicine.

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单细胞组学进展：在基础和临床研究中的变革性应用

单细胞RNA测序、空间转录组学和多组学整合的最新进展使研究人员能够解剖复杂组织并识别具有独特功能状态的不同细胞群。这篇综述讨论了单细胞组学在不同领域的应用，包括癌症研究和发育生物学，展示了它们如何揭示细胞相互作用、疾病机制和治疗反应。值得注意的研究表明，单细胞方法在发现新的生物标志物和治疗靶点方面具有潜力，特别是在癌症和神经发育障碍等异质性疾病中。此外，该综述强调了将单细胞数据与计算模型相结合的重要性，以增强我们对细胞动力学和微环境影响的理解。总的来说，这篇综述强调了单细胞组学在推进我们的生物学知识及其在临床环境中的应用方面的关键作用，为个性化医疗铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.