Invasive Trichoderma longibrachiatum breakthrough infection in a hematology patient

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Yuri Vanbiervliet , Robina Aerts , Ellen Boon , Toine Mercier , Ann-Sophie Jacob , Marijke Peetermans , Koen Debackere , Katrien Lagrou , Johan Maertens
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引用次数: 0

Abstract

Trichoderma species are emerging as pathogens, causing invasive fungal infections, particularly in immunocompromised individuals. We report the case of a 61-year-old neutropenic female with hepatosplenic T-cell lymphoma and profound neutropenia, who developed a breakthrough infection with Trichoderma longibrachiatum while receiving liposomal amphotericin B for probable invasive pulmonary aspergillosis. Despite combination antifungal therapy the patient ultimately succumbed to multiple organ failure. Trichoderma longibrachiatum and Aspergillus fumigatus were identified as causative fungal pathogens. Antifungal susceptibility testing of the T. longibrachiatum isolate revealed resistance to isavuconazole but susceptibility to amphotericin B, voriconazole, itraconazole and olorofim.
血液学患者侵袭性长尾木霉突破感染1例
木霉作为病原体出现,引起侵袭性真菌感染,特别是在免疫功能低下的个体中。我们报告一例61岁中性粒细胞减少的女性,患有肝脾t细胞淋巴瘤和深度中性粒细胞减少症,她在接受脂质两性霉素B治疗可能的侵袭性肺曲霉病时发生了突破性的长直链木霉感染。尽管联合抗真菌治疗,患者最终死于多器官衰竭。鉴定出病原菌为长直链木霉和烟曲霉。长尾通虫抗真菌药敏试验显示,长尾通虫对异戊康唑耐药,对两性霉素B、伏立康唑、伊曲康唑和奥洛芬敏感。
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来源期刊
Medical Mycology Case Reports
Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.00
自引率
0.00%
发文量
48
审稿时长
47 days
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