Parental autoimmunity genetics and offspring type 1 diabetes risk.

Abstract

Many children presenting with type 1 diabetes have a family history of the disorder or another autoimmune disease. In this issue of Cell Genomics, Wang et al.¹ use extensive clinical and genetic databases to identify the genetic factors contributing to this familial aggregation and develop polygenic risk scores that predict pediatric type 1 diabetes pathogenesis with high accuracy.