Associations and Interactions Between Neuroticism, Adverse Life Events and Health Anxiety: Results From a Large Representative Cohort.

IF 2.4 Q2 Psychology

Clinical Psychology in Europe Pub Date : 2025-05-28 eCollection Date: 2025-05-01 DOI:10.32872/cpe.14441

Thomas Tandrup Lamm, Mimi Yung Mehlsen, Tina Birgitte Wisbech Carstensen, Kaare Bro Wellnitz, Eva Ørnbøl, Thomas Meinertz Dantoft, Per Fink, Marie Weinreich Petersen, Lisbeth Frostholm

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Abstract

Purpose: Adverse life events and neuroticism have been shown to be associated with health anxiety (HA), but their interaction has not been studied. This study aimed to examine the separate associations as well as the possible interaction effect of neuroticism and adverse life events with HA.

Method: Cross-sectional self-report data originated from a representative Danish population cohort (DanFunD) (N = 7,493, 18-72 years, 53% females). Primary measures were HA (Whiteley Index 6 revised), neuroticism (NEO personality Inventory Revised short form), and adverse life events (Cumulative Lifetime Adversity Measure, CLAM). The CLAM was split into illness/death related life events (IDE) and other adverse life events (OAE) to test the specificity of IDEs.

Results: Adjusted ordinal logistic regression models showed positive associations with HA for IDEs (OR = 1.05, CI [1.03, 1.08]), OAEs (OR = 1.05, CI [1.03, 1.07]) and neuroticism (OR = 1.08, CI [1.07, 1.09]). A Wald's test revealed no difference in association with HA for IDEs and OAEs (p = .82). Adjusted models showed an interaction effect for neuroticism*IDEs (OR = 1.002, CI [1.000, 1.004]), but not for neuroticism*OAEs (OR = 0.999, CI [0.996, 1.002]).

Conclusion: Associations with HA were found for both adverse life events and neuroticism. Size of association did not differ for IDEs and OAEs. Only IDEs interacted with neuroticism.

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神经质、不良生活事件和健康焦虑之间的关联和相互作用：来自一个大型代表性队列的结果。

目的：不良生活事件和神经质已被证明与健康焦虑（HA）相关，但它们之间的相互作用尚未被研究。本研究旨在探讨神经过敏和不良生活事件与血凝素之间的独立关联以及可能的相互作用。方法：横断面自我报告数据来自具有代表性的丹麦人群队列（DanFunD）（N = 7,493, 18-72岁，53%为女性）。主要测量是HA （Whiteley Index 6 revised）、神经质（NEO personality Inventory revised short form）和不良生活事件（Cumulative Lifetime逆境测量，CLAM）。CLAM分为疾病/死亡相关生活事件（IDE）和其他不良生活事件（OAE），以检测IDE的特异性。结果：调整后的有序logistic回归模型显示ide （OR = 1.05, CI[1.03, 1.08]）、oae （OR = 1.05, CI[1.03, 1.07]）和神经质（OR = 1.08, CI[1.07, 1.09]）与HA呈正相关。Wald's检验显示ide和oae与HA的相关性无差异（p = 0.82）。调整后的模型显示，神经质* ide存在交互作用（OR = 1.002, CI[1.000, 1.004]），神经质* oae不存在交互作用（OR = 0.999, CI[0.996, 1.002]）。结论：HA与不良生活事件和神经质均有关联。ide和oae的关联大小没有差异。只有ide与神经质相互作用。

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