Nanofiber-Based Biomimetic Platforms for Chronic Wound Healing: Recent Innovations and Future Directions.

IF 4.4 4区医学 Q2 CELL & TISSUE ENGINEERING

Tissue engineering and regenerative medicine Pub Date : 2025-06-13 DOI:10.1007/s13770-025-00729-6

Mina Kwon, Ki Su Kim

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引用次数: 0

Abstract

Background: Wound healing remains a significant challenge in healthcare, particularly for complex and chronic wounds where conventional treatments often fail to provide effective solutions. Recent advances in nanofiber technology have opened new avenues for wound management by offering biomimetic structures that support tissue regeneration. Due to their high surface area-to-volume ratio and porosity, nanofibers closely resemble the extracellular matrix, facilitating an optimal environment for cell adhesion, proliferation, and differentiation.

Methods: This review examines the role of nanofiber-based wound dressings, highlighting their unique advantages in drug delivery, moisture retention, and antimicrobial protection. Additionally, emerging trends such as smart wound dressings responsive to environmental stimuli and multifunctional nanofiber systems are discussed.

Results and conclusion: Nanofiber technology has demonstrated significant potential in enhancing wound healing outcomes by providing an advanced platform for therapeutic delivery and tissue regeneration. Furthermore, the integration of nanofibers with artificial intelligence and biotechnology offers promising directions for future research. As these innovations continue to evolve, nanofiber-based wound dressings may revolutionize wound care by enabling more personalized and effective treatment strategies.

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基于纳米纤维的慢性伤口愈合仿生平台：最近的创新和未来的方向。

背景：伤口愈合仍然是医疗保健中的一个重大挑战，特别是对于复杂和慢性伤口，常规治疗往往不能提供有效的解决方案。纳米纤维技术的最新进展通过提供支持组织再生的仿生结构，为伤口管理开辟了新的途径。由于其高表面积体积比和孔隙率，纳米纤维与细胞外基质非常相似，为细胞粘附、增殖和分化提供了最佳环境。方法：本文综述了纳米纤维伤口敷料的作用，强调了其在给药、保湿和抗菌保护方面的独特优势。此外，还讨论了诸如响应环境刺激的智能伤口敷料和多功能纳米纤维系统等新兴趋势。结果和结论：纳米纤维技术通过提供先进的治疗递送和组织再生平台，在提高伤口愈合结果方面显示出巨大的潜力。此外，纳米纤维与人工智能和生物技术的结合为未来的研究提供了很好的方向。随着这些创新的不断发展，纳米纤维伤口敷料可能会通过实现更个性化和有效的治疗策略，彻底改变伤口护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue engineering and regenerative medicine CELL & TISSUE ENGINEERING-ENGINEERING, BIOMEDICAL

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Tissue Engineering and Regenerative Medicine (Tissue Eng Regen Med, TERM), the official journal of the Korean Tissue Engineering and Regenerative Medicine Society, is a publication dedicated to providing research- based solutions to issues related to human diseases. This journal publishes articles that report substantial information and original findings on tissue engineering, medical biomaterials, cells therapy, stem cell biology and regenerative medicine.