A State-of-the-Art Review on Recent Biomedical Application of Polysaccharide-Based Niosomes as Drug Delivery Systems.

IF 4.7 3区工程技术 Q1 POLYMER SCIENCE

Polymers Pub Date : 2025-06-04 DOI:10.3390/polym17111566

Andreea-Teodora Iacob, Andra Ababei-Bobu, Oana-Maria Chirliu, Florentina Geanina Lupascu, Ioana-Mirela Vasincu, Maria Apotrosoaei, Bianca-Stefania Profire, Georgiana-Roxana Tauser, Dan Lupascu, Lenuta Profire

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引用次数: 0

Abstract

The development of nanocarriers for drug delivery has drawn a lot of attention due to the possibility for tailored delivery to the ill region while preserving the neighboring healthy tissue. In medicine, delivering drugs safely and effectively has never been easy; therefore, the creation of surfactant-based vesicles (niosomes) to enhance medication delivery has gained attention in the past years. Niosomes (NIOs) are versatile drug delivery systems that facilitate applications varying from transdermal transport to targeted brain delivery. These self-assembling vesicular nano-carriers are formed by hydrating cholesterol, non-ionic surfactants, and other amphiphilic substances. The focus of the review is to report on the latest NIO-type formulations which also include biopolymers from the polysaccharide class, highlighting their role in the development of these drug delivery systems (DDSs). The NIO and polysaccharide types, together with the recent pharmaceutical applications such as ocular, oral, nose-to brain, pulmonary, cardiac, and transdermal drug delivery, are all thoroughly summarized in this review, which offers a comprehensive compendium of polysaccharide-based niosomal research to date. Lastly, this delivery system's limits and prospects are also examined.

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多糖基膜小体作为药物传递系统的生物医学应用研究进展。

纳米药物载体的发展引起了人们的广泛关注，因为它可以在保留邻近健康组织的同时，对患病区域进行量身定制的药物递送。在医学领域，安全有效地给药从来都不是一件容易的事；因此，在过去的几年里，基于表面活性剂的囊泡（niosome）的创建来增强药物传递已经引起了人们的关注。Niosomes （NIOs）是一种多功能的药物递送系统，可促进从透皮转运到靶向脑递送的各种应用。这些自组装的囊状纳米载体是由水合胆固醇、非离子表面活性剂和其他两亲性物质形成的。综述的重点是报告最新的nio型配方，其中也包括来自多糖类的生物聚合物，强调它们在这些药物递送系统（dds）开发中的作用。本文对NIO和多糖类型及其在眼、口、鼻到脑、肺、心脏和透皮等药物传递方面的最新应用进行了全面的综述，提供了迄今为止基于多糖的niosomal研究的综合概要。最后，对该传输系统的局限性和前景进行了分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymers POLYMER SCIENCE-

CiteScore

8.00

自引率

16.00%

发文量

4697

审稿时长

1.3 months

期刊介绍： Polymers (ISSN 2073-4360) is an international, open access journal of polymer science. It publishes research papers, short communications and review papers. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Polymers provides an interdisciplinary forum for publishing papers which advance the fields of (i) polymerization methods, (ii) theory, simulation, and modeling, (iii) understanding of new physical phenomena, (iv) advances in characterization techniques, and (v) harnessing of self-assembly and biological strategies for producing complex multifunctional structures.