Clinical Applications and Mechanisms of Klotho in Periodontitis Diagnosis and Therapy.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-06-12 DOI:10.1111/odi.15402

Chengyu Wan, Yalan Yang, Bozhao Wang, Jian Li

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引用次数: 0

Abstract

Objectives: Periodontitis is a prevalent chronic inflammatory condition affecting the periodontal supporting tissue, and Klotho has anti-inflammatory and antioxidant effects. In recent years, some emerging evidence has revealed a link between Klotho and periodontitis. This review aims to elucidate the effects of Klotho in periodontitis and summarize the methods to increase Klotho levels for clinical treatment.

Subjects and methods: We conducted a systematic search of PubMed, Web of Science, and Embase databases to review the current research status of Klotho in relation to periodontitis and its roles in periodontal disease mechanisms.

Results: Klotho demonstrates anti-inflammatory, antioxidant, autophagy-enhancing, and alveolar bone regeneration-promoting effects in periodontitis. Feasible strategies to elevate Klotho levels in humans include exogenous supplementation of Klotho and modulation of its upstream regulatory pathways.

Conclusion: Klotho and its associated enhancers show significant therapeutic potential for the management of periodontitis; however, the underlying mechanisms and more clinical studies are still lacking, and further research is needed.

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Klotho在牙周炎诊治中的临床应用及作用机制。

目的：牙周炎是一种影响牙周支持组织的常见慢性炎症，克罗索具有抗炎和抗氧化作用。近年来，一些新出现的证据揭示了Klotho和牙周炎之间的联系。本文旨在阐明Klotho在牙周炎中的作用，并总结提高Klotho水平用于临床治疗的方法。研究对象和方法：我们对PubMed、Web of Science和Embase数据库进行了系统检索，回顾了Klotho与牙周炎相关的研究现状及其在牙周病机制中的作用。结果：Klotho对牙周炎具有抗炎、抗氧化、增强自噬和促进牙槽骨再生的作用。提高人类Klotho水平的可行策略包括外源性补充Klotho和调节其上游调控途径。结论：Klotho及其相关增强剂对牙周炎具有显著的治疗潜力；然而，其潜在的机制和更多的临床研究仍然缺乏，需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.