{"title":"The history of entamoebiasis.","authors":"Dietmar Steverding","doi":"10.1017/S0031182025100279","DOIUrl":null,"url":null,"abstract":"<p><p>This review article summarizes the history of amoebic dysentery (entamoebiasis) caused by <i>Entamoeba histolytica</i>. Initially, <i>Entamoeba</i> species were thought to be the most primitive extant eukaryotes, but more recent research revealed that they emerged relatively late in evolutionary history. Paleoparasitological data suggest that <i>E. histolytica</i> has been a parasite of humans since ancient times and was probably spread throughout the world by man during early human migration. By the end of the 19th century, it was established that <i>E. histolytica</i> was the etiological agent of amoebic dysentery and liver abscess. The issue over pathogenic and non-pathogenic strains of <i>E. histolytica</i> was resolved in the 1980s by the discovery of the morphologically indistinguishable harmless sister species <i>Entamoeba dispar</i>. Being mainly a disease of tropical and subtropical low-income countries, entamoebiasis cases have increased among travellers and immigrants arriving from endemic regions in recent years.</p>","PeriodicalId":19967,"journal":{"name":"Parasitology","volume":" ","pages":"563-572"},"PeriodicalIF":2.4000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278010/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0031182025100279","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This review article summarizes the history of amoebic dysentery (entamoebiasis) caused by Entamoeba histolytica. Initially, Entamoeba species were thought to be the most primitive extant eukaryotes, but more recent research revealed that they emerged relatively late in evolutionary history. Paleoparasitological data suggest that E. histolytica has been a parasite of humans since ancient times and was probably spread throughout the world by man during early human migration. By the end of the 19th century, it was established that E. histolytica was the etiological agent of amoebic dysentery and liver abscess. The issue over pathogenic and non-pathogenic strains of E. histolytica was resolved in the 1980s by the discovery of the morphologically indistinguishable harmless sister species Entamoeba dispar. Being mainly a disease of tropical and subtropical low-income countries, entamoebiasis cases have increased among travellers and immigrants arriving from endemic regions in recent years.
期刊介绍：
Parasitology is an important specialist journal covering the latest advances in the subject. It publishes original research and review papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in parasite biochemistry, molecular biology and genetics, ecology and epidemiology in the context of the biological, medical and veterinary sciences. Included in the subscription price are two special issues which contain reviews of current hot topics, one of which is the proceedings of the annual Symposia of the British Society for Parasitology, while the second, covering areas of significant topical interest, is commissioned by the editors and the editorial board.
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