Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrients Pub Date : 2025-06-05 DOI:10.3390/nu17111939

Anna Gościniak, Anna Stasiłowicz-Krzemień, Marta Szeląg, Jakub Pawlak, Izabela Skiera, Hanna Kwiatkowska, Natasza Nowak, Krzysztof Bernady, Piotr Trzaskoma, Oskar Zimak-Krótkopad, Judyta Cielecka-Piontek

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引用次数: 0

Abstract

Bacopa monnieri, also known as Brahmi or Waterhyssop, is a plant used in Ayurveda for its memory-enhancing properties and control of blood sugar levels. It contains active compounds such as alkaloids, saponins, and cucurbitacins, which have various biological activities. The plant has been studied for its potential in treating Alzheimer's disease, Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and depression. Animal studies have shown promising results in reducing symptoms and protecting against neurodegeneration. Concerning safety, Bacopa monnieri has been found to be generally non-toxic, with no serious side effects reported. However, interactions with certain medications and contraindications in conditions like hyperthyroidism should be considered. Further research is needed to determine optimal dosages and ensure safety, especially for pregnant and breastfeeding women.

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假马齿苋：神经活性作用的临床前和临床证据，使用安全性和提高生物利用度的研究。

假马齿苋（Bacopa monnieri），也被称为婆罗门草（Brahmi）或水牛膝草（Waterhyssop），是印度草药中使用的一种植物，具有增强记忆和控制血糖水平的特性。它含有生物碱、皂苷、葫芦素等活性化合物，具有多种生物活性。人们已经研究了这种植物在治疗阿尔茨海默病、帕金森病、注意力缺陷多动障碍（ADHD）和抑郁症方面的潜力。动物研究已经显示出在减轻症状和防止神经变性方面有希望的结果。在安全性方面，假马齿苋已被发现一般无毒，没有严重的副作用报道。然而，应考虑与某些药物的相互作用以及甲亢等疾病的禁忌症。需要进一步研究以确定最佳剂量并确保安全性，特别是对孕妇和哺乳期妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.