Preparation and Properties of Calcium Peroxide/Poly(ethylene glycol)@Silica Nanoparticles with Controlled Oxygen-Generating Behaviors.

IF 3.1 3区材料科学 Q3 CHEMISTRY, PHYSICAL

Materials Pub Date : 2025-05-30 DOI:10.3390/ma18112568

Xiaoling Xie, Xin Sun, Wanming Lin, Xiaofeng Yang, Ruicong Wang

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引用次数: 0

Abstract

The hypoxic microenvironment is the main challenge for the repair of damaged tissue, and oxygen supply is an effective means of alleviating hypoxia. In this study, a series of core-shell-structured calcium peroxide/poly(ethylene glycol)@silica (CPO@SiO₂) nanoparticles are prepared to generate oxygen steadily. The size of the CPO@SiO₂ nanoparticles ranges from 205 to 302 nm, with a narrow polydispersity index (PDI). In this system, the nano CPO core acts as the oxygen source to improve hypoxia, while the SiO₂ shell layer serves as the physical barrier to control the oxygen-generating rate and improve biocompatibility. The results suggest that the thickness of the SiO₂ shell layer can be modulated by adjusting the amount of tetraethyl orthosilicate (TEOS). The prepared CPO@SiO₂ nanoparticles show a controlled oxygen-generating rate. Moreover, compared with CPO, the CPO@SiO₂ nanoparticles have good biocompatibility. To assess the modulating effects for the hypoxic microenvironment, L929 cells are co-cultured with CPO@ SiO₂ nanoparticles under hypoxia. The results suggest that the CPO@ SiO₂ nanoparticles can support the cell survival under hypoxia. Moreover, they can effectively decrease oxidative stress damage and reduce the levels of expression of hypoxia-induced superoxide dismutase (SOD) and malondialdehyde (MDA). Therefore, the prepared CPO@ SiO₂ nanoparticles with controlled oxygen-generating properties could be a promising candidate for repairing damaged tissue.

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具有可控产氧行为的过氧化钙/聚乙二醇@二氧化硅纳米颗粒的制备与性能

缺氧微环境是损伤组织修复的主要挑战，供氧是缓解缺氧的有效手段。在本研究中，制备了一系列核壳结构的过氧化钙/聚乙二醇@二氧化硅（CPO@SiO2）纳米颗粒，以稳定生成氧气。CPO@SiO2纳米颗粒的粒径在205 ~ 302 nm之间，具有较窄的多分散性指数（PDI）。在该体系中，纳米CPO核作为氧源改善缺氧，SiO2壳层作为物理屏障控制产氧速率，提高生物相容性。结果表明，可以通过调节正硅酸四乙酯（TEOS）的用量来调节SiO2壳层的厚度。制备的CPO@SiO2纳米颗粒表现出可控的产氧速率。此外，与CPO相比，CPO@SiO2纳米颗粒具有良好的生物相容性。为了评估低氧微环境对L929细胞的调节作用，我们在缺氧条件下将L929细胞与CPO@ SiO2纳米颗粒共培养。结果表明，CPO@ SiO2纳米颗粒能够支持细胞在缺氧条件下的存活。此外，它们还能有效减轻氧化应激损伤，降低缺氧诱导的超氧化物歧化酶（SOD）和丙二醛（MDA）的表达水平。因此，制备的CPO@ SiO2纳米颗粒具有可控的产氧性能，可能是修复损伤组织的有希望的候选材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

5.80

自引率

14.70%

发文量

7753

审稿时长

1.2 months

期刊介绍： Materials (ISSN 1996-1944) is an open access journal of related scientific research and technology development. It publishes reviews, regular research papers (articles) and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Materials provides a forum for publishing papers which advance the in-depth understanding of the relationship between the structure, the properties or the functions of all kinds of materials. Chemical syntheses, chemical structures and mechanical, chemical, electronic, magnetic and optical properties and various applications will be considered.