Caterina Saija, Maria Paola Bertuccio, Monica Currò, Daniela Caccamo
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引用次数: 0
Abstract
Early predictive markers of bone resorption are required to plan intervention strategies ensuring a healthy aging. Collagen I C-telopeptide (CTX) as bone activity marker shows a fair biological variability, that cause the lack of a well-defined reference range. Given the well-established role of vitamin D in bone remodeling, the aim of this study was to assess the influence of vitamin D status on the variability of CTX serum levels in 131 pre-menopausal (45-54 years) and 951 post-menopausal women (55-90 years). Serum CTX and vitamin D levels were assessed, respectively, by ELISA and HPLC determination of 25-hydroxy-vitamin D3. A significantly negative dependence of CTX on vitamin D3, but not age, was found in the whole study cohort (B = -0.170, p<0.0001). A significantly negative correlation between CTX and vitamin D3 was found both in pre-menopausal (r = -0.2614; p = 0.0061) and post-menopausal women (r = -0.2220; p<0.0001), and confirmed in post-menopausal women aged 55 to 59 years (r = -0.2840, p = 0.0061), 60 to 64 years (r = -0.2143, p = 0.0129), and 70 to 74 years (r = -0.3078, p<0.0001). These findings suggest that vitamin D status determination and early vitamin D supplementation may be required in women at higher risk of bone resorption because of the physiologically reduced protective effects of estrogens.
期刊介绍:
Journal of Clinical Biochemistry and Nutrition (JCBN) is
an international, interdisciplinary publication encompassing
chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The
Journal welcomes original contributions dealing with all
aspects of clinical biochemistry and clinical nutrition
including both in vitro and in vivo studies.