Influence of vitamin D status on the variability of collagen I C-telopeptide in pre- and post-menopausal healthy women.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-05-01 Epub Date: 2025-02-08 DOI:10.3164/jcbn.24-146
Caterina Saija, Maria Paola Bertuccio, Monica Currò, Daniela Caccamo
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引用次数: 0

Abstract

Early predictive markers of bone resorption are required to plan intervention strategies ensuring a healthy aging. Collagen I C-telopeptide (CTX) as bone activity marker shows a fair biological variability, that cause the lack of a well-defined reference range. Given the well-established role of vitamin D in bone remodeling, the aim of this study was to assess the influence of vitamin D status on the variability of CTX serum levels in 131 pre-menopausal (45-54 years) and 951 post-menopausal women (55-90 years). Serum CTX and vitamin D levels were assessed, respectively, by ELISA and HPLC determination of 25-hydroxy-vitamin D3. A significantly negative dependence of CTX on vitamin D3, but not age, was found in the whole study cohort (B = -0.170, p<0.0001). A significantly negative correlation between CTX and vitamin D3 was found both in pre-menopausal (r = -0.2614; p = 0.0061) and post-menopausal women (r = -0.2220; p<0.0001), and confirmed in post-menopausal women aged 55 to 59 years (r = -0.2840, p = 0.0061), 60 to 64 years (r = -0.2143, p = 0.0129), and 70 to 74 years (r = -0.3078, p<0.0001). These findings suggest that vitamin D status determination and early vitamin D supplementation may be required in women at higher risk of bone resorption because of the physiologically reduced protective effects of estrogens.

维生素D水平对绝经前和绝经后健康女性I型胶原c端肽变异性的影响
骨吸收的早期预测标记是制定干预策略以确保健康老龄化所必需的。胶原c -末端肽(CTX)作为骨活性标记物具有一定的生物学变异性,因此缺乏明确的参考范围。考虑到维生素D在骨重塑中的作用,本研究的目的是评估131名绝经前(45-54岁)和951名绝经后(55-90岁)妇女维生素D状态对CTX血清水平变异性的影响。采用ELISA法和HPLC法测定25-羟基维生素D3,分别测定血清CTX和维生素D水平。在整个研究队列中(B = -0.170, pp = 0.0061)和绝经后妇女(r = -0.2220;Pp = 0.0061), 60 ~ 64岁(r = -0.2143, p = 0.0129), 70 ~ 74岁(r = -0.3078, p = 0.0129)
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来源期刊
CiteScore
4.30
自引率
8.30%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.
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