Olanzapine-induced paraesthesia: A less reported side effect.

Abstract

Abstract: Olanzapine is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and depression. Despite proven efficacy in these disorders, it can cause various side effects, including occurrences of paraesthesia-a sensory disorder characterized by spontaneous itching or tingling without external triggers. The mechanism behind olanzapine-induced paraesthesia is not well understood but may involve dopamine D2 and serotonin 5-HT2A and 5-HT2C receptor antagonism. Here, we report two cases of severe paraesthesia that occurred as a side effect of olanzapine therapy, which improved after discontinuing the medication in the first case and by reducing the dose in the second case.