Antimicrobial Activities of Five Different Soap Types Combined with an Extract from Eucalyptus camaldulensis.

IF 1.7 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Combinatorial chemistry & high throughput screening Pub Date : 2025-06-12 DOI:10.2174/0113862073381870250523035135

Muna Jalal Ali, Emel Eker, Suzan Adil Rashid Al-Naqeeb, Manaf AlMatar

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引用次数: 0

Abstract

Background: Soaps are vital for preserving our health and personal hygiene since they not only eliminate germs but also rid the body of pollutants.

Method: The current study aims to determine the physicochemical and antibacterial properties of Eucalyptus camaldulensis leaves using the agar disc diffusion technique and assess the effectiveness of different branded liquid soaps (25 mg/ml, 50 mg/ml, 75 mg/ml, and 100 mg/ml) with the Eucalyptus leaf extract against skin-infecting human pathogenic bacteria.

Results: The combined antimicrobial susceptibility of E. camaldulensis and five liquid soaps showed an inhibition zone of 17.67±0.58, 13.33±0.58, 12.67±0.58, and 15.67±0.58 against Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, and Escherichia coli. The antibacterial properties of Av soap by itself did not work against S. pyogenes. Nevertheless, the extract and DI together showed a detrimental effect against S. aureus and P. aeruginosa, with no halo forming.

Conclusion: Antimicrobial activity was observed to increase with higher concentrations of the soap-extract combinations. Although liquid soap (seve) was effective against bacterial isolates, a combination of eucalyptus and aqua vera was shown to be more effective.

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五种不同皂类与桉叶提取物复合的抗菌活性。

背景：肥皂对保持我们的健康和个人卫生至关重要，因为它们不仅可以消灭细菌，还可以清除体内的污染物。方法：采用琼脂盘扩散法测定桉树叶的理化特性和抗菌性能，并评价不同品牌桉树叶提取物液体皂（25 mg/ml、50 mg/ml、75 mg/ml和100 mg/ml）对皮肤感染人类致病菌的抑菌效果。结果：5种液体皂对茶树绿脓杆菌、金黄色葡萄球菌、化脓性链球菌、铜绿假单胞菌和大肠杆菌的联合药敏区分别为17.67±0.58、13.33±0.58、12.67±0.58和15.67±0.58。Av皂本身的抗菌性能对化脓性葡萄球菌不起作用。然而，提取物和DI一起对金黄色葡萄球菌和铜绿假单胞菌表现出有害的作用，没有形成晕。结论：皂提物的抑菌活性随皂提物浓度的增加而增强。虽然液体肥皂（seve）对细菌分离有效，但桉树和海藻的组合被证明更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Combinatorial chemistry & high throughput screening 化学-生化研究方法

CiteScore

3.10

自引率

5.60%

发文量

327

审稿时长

7.5 months

期刊介绍： Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.