Rheumatoid Arthritis and Risk of Thyroid Cancer: A Nationwide Cohort Study

IF 3.3 2区医学 Q1 RHEUMATOLOGY

Arthritis Care & Research Pub Date : 2025-06-13 DOI:10.1002/acr.25582

Mi Hee Cho, Jinhyung Jung, Tae Hyuk Kim, Kyungdo Han, Dagyeong Lee, Keun Hye Jeon, In Young Cho, Dong Wook Shin

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Abstract

Objective

Despite extensive cancer-related research in patients with rheumatoid arthritis (RA), there remains a paucity of studies on thyroid cancer in patients with RA. We investigated the risk of thyroid cancer in patients with RA using updated definitions to identify patients with RA and incident cases of thyroid cancer with consideration of RA serologic status.

Methods

Using a nationwide database, we identified 40,895 patients with newly diagnosed RA between 2010 and 2017 and matched them by sex and age at a 1:5 ratio to a control population of 204,475 individuals without RA. The association of thyroid cancer and RA with consideration of serostatus was investigated using Cox regression analyses. Stratified analyses by sex and age were conducted using the same Cox modeling.

Results

During 5.5 years of follow-up, compared to the matched control group, the adjusted hazard ratio (aHR) of thyroid cancer in patients with overall RA was 0.98 (95% confidence interval [CI] 0.85–1.13). Compared to the seronegative patients with RA, seropositive patients with RA did not show a significantly different risk of thyroid cancer (aHR 1.03, 95% CI 0.78–1.36). Stratified analyses by age or sex showed no statistical interaction.

Conclusion

Patients with newly diagnosed RA did not show a different risk of thyroid cancer compared to a matched control group. The risk of thyroid cancer incidence was not affected by serologic status of RA, sex, or age.

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类风湿关节炎和甲状腺癌的风险：一项全国性队列研究。

目的：尽管类风湿关节炎（RA）患者的癌症相关研究广泛，但类风湿关节炎患者甲状腺癌的研究仍然缺乏。我们调查了RA患者甲状腺癌的风险，使用更新的定义来确定RA患者和甲状腺癌的发生率，并考虑RA血清学状态。方法：使用全国数据库，我们确定了2010年至2017年期间40,895名新诊断的RA患者，并将其按性别和年龄按1:5的比例与204,475名非RA个体的对照人群进行匹配。采用Cox回归分析研究甲状腺癌和RA与血清状态的关系。采用相同的Cox模型，按性别和年龄进行分层分析。结果：在5.5年的随访中，与匹配的对照组相比，RA患者甲状腺癌的调整风险比（aHR）为0.98（95%可信区间[CI] 0.85-1.13）。与血清阴性RA患者相比，血清阳性RA患者患甲状腺癌的风险无显著差异（aHR 1.03, 95% CI 0.78-1.36）。年龄或性别的分层分析显示没有统计学上的相互作用。结论：与匹配的对照组相比，新诊断的RA患者没有显示出不同的甲状腺癌风险。甲状腺癌发生的风险不受类风湿关节炎的血清学状况、性别或年龄的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis Care & Research RHEUMATOLOGY-

CiteScore

9.40

自引率

6.40%

发文量

368

审稿时长

3-6 weeks

期刊介绍： Arthritis Care & Research, an official journal of the American College of Rheumatology and the Association of Rheumatology Health Professionals (a division of the College), is a peer-reviewed publication that publishes original research, review articles, and editorials that promote excellence in the clinical practice of rheumatology. Relevant to the care of individuals with rheumatic diseases, major topics are evidence-based practice studies, clinical problems, practice guidelines, educational, social, and public health issues, health economics, health care policy, and future trends in rheumatology practice.