Chlorhexidine loaded nanomaterials for dental plaque control: enhanced antibacterial activity and biocompatibility.

IF 3.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Biomedical Microdevices Pub Date : 2025-06-13 DOI:10.1007/s10544-025-00755-0

Aram Rostami, Vahid Molabashi, Saber Ganji, Seyedeh Parvaneh Moosavi, Alireza Koushki, Sonia Fathi-Karkan, Kianoosh Ghaderi, Mehdi Shahgolzari

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引用次数: 0

Abstract

Chlorhexidine (Chx) is a commonly used antimicrobial agent in dentistry, but its effectiveness can be limited due to rapid clearance, potential cytotoxicity, and insufficient tissue penetration. Nanomaterials have been developed as carriers for Chx, can offer a solution by adapting to environmental changes during disease states and enabling targeted drug delivery. This study explores Chx-loaded nanomaterials, which show enhanced antibacterial properties, promote tissue regeneration, and facilitate drug diffusion. Results show sustained drug release profiles and significantly enhanced antimicrobial activity compared to free Chx. In vitro studies confirm their effectiveness against key dental pathogens while maintaining excellent biocompatibility with human gingival fibroblasts and periodontal ligament cells. Future research should focus on optimizing the formulation and delivery methods of these nanomaterials to ensure safe, effective treatment of dental infections.

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氯己定负载纳米材料用于牙菌斑控制：增强抗菌活性和生物相容性。

氯己定（Chx）是一种常用的牙科抗菌剂，但由于清除迅速、潜在的细胞毒性和组织渗透不足，其有效性可能受到限制。纳米材料已经被开发出来作为Chx的载体，可以提供一种解决方案，通过适应疾病状态期间的环境变化和实现靶向给药。本研究探索了负载chx的纳米材料，其具有增强的抗菌性能，促进组织再生，促进药物扩散。结果显示，与游离Chx相比，Chx具有持续的药物释放特征和显著增强的抗菌活性。体外研究证实了它们对关键牙齿病原体的有效性，同时与人类牙龈成纤维细胞和牙周韧带细胞保持良好的生物相容性。未来的研究重点应放在优化这些纳米材料的配方和递送方法上，以确保安全、有效地治疗牙齿感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.