Dynamic of infectious aerosols generated by cough from patients with pulmonary tuberculosis

IF 2.9 3区 环境科学与生态学 Q2 ENGINEERING, CHEMICAL
Taline Canto Tristão , Mariana Abou Mourad Ferreira , Pedro Sousa de Almeida Júnior , Luiz Guilherme Schmidt Castellani , Manuela Negrelli Brunetti , Edward C. Jones-López , Kevin P. Fennelly , Michael R. Barer , Carlos Henrique Fantecelle , Saulo Almeida Morellato , David Jamil Hadad , Jerrold J. Ellner , Reynaldo Dietze , Moisés Palaci
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Abstract

Tuberculosis (TB) is an ancient disease transmitted through aerosols frequently generated by coughing and it is still unknown whether there is variability in cough aerosol output throughout the day and whether this may impact patients’ infectivity categorization. To study the dynamic of infectious aerosols generated by cough, we conducted a cross-sectional study on pulmonary TB patients (n = 16) who had their cough-generated aerosols sampled twice daily for two consecutive days for the Cough Aerosol Sampling System (CASS) assay. Most patients were classified as Variable Low Producers and Variable High Producers (n = 10; 62.5 %), followed by Negative Producers (n = 4; 25 %) and Consistent Producers (n = 2; 12.5 %). Additionally, most recovered bacilli (88.7 %) within a respiratory aerosol size range. Although the time of collection did not appear to impact on aerosol infectivity, performing CASS with multiple samples allowed for more accurate detection and distinction among aerosol producers.
肺结核患者咳嗽产生的传染性气溶胶的动态
结核病(TB)是一种古老的疾病,经常通过咳嗽产生的气溶胶传播,目前尚不清楚全天咳嗽气溶胶的输出是否存在变异性,以及这是否会影响患者的传染性分类。为了研究咳嗽产生的传染性气溶胶的动态,我们对肺结核患者(n = 16)进行了一项横断面研究,这些患者连续两天每天两次对咳嗽产生的气溶胶进行采样,以进行咳嗽气溶胶采样系统(CASS)测定。大多数患者分为可变低生产者和可变高生产者(n = 10;62.5%),其次是消极生产者(n = 4;25%)和一致性生产者(n = 2;12.5%)。此外,大多数回收的杆菌(88.7%)在呼吸道气溶胶大小范围内。虽然收集时间似乎对气溶胶传染性没有影响,但对多个样本进行CASS可以更准确地检测和区分气溶胶生产者。
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来源期刊
Journal of Aerosol Science
Journal of Aerosol Science 环境科学-工程:化工
CiteScore
8.80
自引率
8.90%
发文量
127
审稿时长
35 days
期刊介绍: Founded in 1970, the Journal of Aerosol Science considers itself the prime vehicle for the publication of original work as well as reviews related to fundamental and applied aerosol research, as well as aerosol instrumentation. Its content is directed at scientists working in engineering disciplines, as well as physics, chemistry, and environmental sciences. The editors welcome submissions of papers describing recent experimental, numerical, and theoretical research related to the following topics: 1. Fundamental Aerosol Science. 2. Applied Aerosol Science. 3. Instrumentation & Measurement Methods.
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