Adsorption equilibrium and diffusion coefficient of baicalein and wogonin in supercritical CO2/methanol

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids Pub Date : 2025-06-10 DOI:10.1016/j.supflu.2025.106692

Zhongfeng Geng , Mingyu Yan , Yongxin Feng , Huisheng Lv

{"title":"Adsorption equilibrium and diffusion coefficient of baicalein and wogonin in supercritical CO2/methanol","authors":"Zhongfeng Geng , Mingyu Yan , Yongxin Feng , Huisheng Lv","doi":"10.1016/j.supflu.2025.106692","DOIUrl":null,"url":null,"abstract":"<div><div>Baicalein, which exhibits antioxidant activity and wogonin, with anticancer activity, can be extracted from <em>Scutellaria baicalensis</em> Georgi. Their similar structures pose a challenge to further isolation. Supercritical Fluid-Simulated Moving Bed (SF-SMB) can function as a large-scale green separation process based on the adsorptive difference between them. The adsorption data of baicalein and wogonin on ZorBax SB-CN column in supercritical carbon dioxide/methanol were determined using the Elution by Characteristic Points method and could be well fitted by Langmuir model. At lower temperature or lower density of mobile phase, the adsorption capacity increased, with the maximum being 70.10 kg/m<sup>3</sup> for baicalein and 45.25 kg/m<sup>3</sup> for wogonin. The diffusion coefficients of the baicalein and wogonin were determined by the Taylor-Aris peak broadening method. They decreased with higher pressure, lower temperature, or higher density of the mobile phase. This work offers basic data support for the design of SF-SMB systems and industrial platform technology.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"225 ","pages":"Article 106692"},"PeriodicalIF":4.4000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Supercritical Fluids","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0896844625001792","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Baicalein, which exhibits antioxidant activity and wogonin, with anticancer activity, can be extracted from Scutellaria baicalensis Georgi. Their similar structures pose a challenge to further isolation. Supercritical Fluid-Simulated Moving Bed (SF-SMB) can function as a large-scale green separation process based on the adsorptive difference between them. The adsorption data of baicalein and wogonin on ZorBax SB-CN column in supercritical carbon dioxide/methanol were determined using the Elution by Characteristic Points method and could be well fitted by Langmuir model. At lower temperature or lower density of mobile phase, the adsorption capacity increased, with the maximum being 70.10 kg/m³ for baicalein and 45.25 kg/m³ for wogonin. The diffusion coefficients of the baicalein and wogonin were determined by the Taylor-Aris peak broadening method. They decreased with higher pressure, lower temperature, or higher density of the mobile phase. This work offers basic data support for the design of SF-SMB systems and industrial platform technology.

查看原文本刊更多论文

黄芩苷和黄芩苷在超临界CO2/甲醇中的吸附平衡及扩散系数

从黄芩中可提取出具有抗氧化活性的黄芩素和具有抗癌活性的黄芩苷。它们相似的结构对进一步孤立构成挑战。超临界流体模拟移动床（SF-SMB）是一种大规模的绿色分离工艺，具有不同的吸附特性。采用特征点洗脱法测定了ZorBax SB-CN柱在超临界二氧化碳/甲醇中对黄芩苷和乌根苷的吸附数据，并用Langmuir模型进行了较好的拟合。在较低的温度或较低的流动相密度下，吸附量增大，黄芩素的最大吸附量为70.10 kg/m3，木犀草素的最大吸附量为45.25 kg/m3。采用泰勒-阿里斯峰展宽法测定了黄芩苷和黄芩苷的扩散系数。它们随流动相的压力增大、温度降低或密度增大而减小。该工作为SF-SMB系统设计和工业平台技术提供了基础数据支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Supercritical Fluids 工程技术-工程：化工

CiteScore

7.60

自引率

10.30%

发文量

236

审稿时长

56 days

期刊介绍： The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.