Epicardial adipose tissue associated with right cardiac chamber remodelling in patients with connective tissue disease evaluated by cardiac magnetic resonance: a cross-sectional study

IF 2.1 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical radiology Pub Date : 2025-05-14 DOI:10.1016/j.crad.2025.106958

Y. Tang , Z. Pan , J. Wen , Z. Yang , D. Tang , Y. Luo , C. Xiang , L. Huang , L. Xia

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引用次数: 0

Abstract

AIM

The present study aimed to evaluate the relationship between epicardial adipose tissue (EAT) and right cardiac chamber remodelling in connective tissue disease (CTD) patients and to investigate the value of EAT in CTD-associated pulmonary hypertension (CTD-PH) patients.

MATERIALS AND METHODS

A total of 134 CTD patients and 64 age- and sex-matched controls who underwent cardiac magnetic resonance (CMR) examination were retrospectively enrolled. Systolic pulmonary arterial pressure (sPAP) measured by transthoracic echocardiography was recorded. Based on combined PH, patients were divided into two subgroups: CTD-PH and CTD-nonPH. Right heart strain parameters and EAT thickness and volume were measured using CVI42 (version 5.13.9, Circle Cardiovascular Imaging Inc., Calgary, Canada). Bootstrapping was used to analyse the mediating effect of right cardiac chamber remodelling between EAT volume index (EATVI) and sPAP in CTD patients. Logistic regression was used to explore the correlations between EAT and CTD-PH.

RESULTS

CTD-PH patients had significantly higher EATVI (43.82 [36.00, 61.27] ml/m² vs. 30.13 [24.06, 41.38] ml/m², P<0.001) and more pronounced right cardiac chamber remodelling than controls. There was a mediating effect between EAT and pulmonary artery pressure in right ventricular myocardial mass index and right atrial conduit function. Multivariate logistic regression showed that EATVI remained an independent association for CTD-PH after adjustment for clinical factors.

CONCLUSION

EAT is significantly increased in CTD-PH patients with more pronounced right cardiac chamber remodelling, which may be one of the valuable parameters for risk stratification of CTD patients.

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心外膜脂肪组织与结缔组织疾病患者右心室重构相关的心脏磁共振：一项横断面研究

目的探讨结缔组织病（CTD）患者心外膜脂肪组织（EAT）与右心室重构的关系，并探讨EAT在CTD相关性肺动脉高压（CTD- ph）患者中的价值。材料与方法回顾性纳入接受心脏磁共振（CMR）检查的134例CTD患者和64例年龄和性别匹配的对照组。记录经胸超声心动图测量的收缩期肺动脉压（sPAP）。根据联合PH，将患者分为两个亚组：CTD-PH和ctd -非PH。使用CVI42（版本5.13.9,Circle Cardiovascular Imaging Inc., Calgary, Canada）测量右心应变参数和EAT厚度和体积。采用Bootstrapping方法分析CTD患者右心室重构在EAT容积指数（EATVI）与sPAP之间的中介作用。采用Logistic回归分析EAT与CTD-PH的相关性。结果sctd - ph患者的EATVI （43.82 [36.00, 61.27] ml/m2 vs. 30.13 [24.06, 41.38] ml/m2, P<0.001）显著高于对照组，右心室重构更为明显。肺动脉压对右心室心肌质量指数和右房导管功能有中介作用。多因素logistic回归分析显示，在调整临床因素后，EATVI仍然是CTD-PH的独立相关性。结论CTD- ph患者右心室重构更为明显，eat明显增高，可能是CTD患者危险分层的重要参数之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical radiology 医学-核医学

CiteScore

4.70

自引率

3.80%

发文量

528

审稿时长

76 days

期刊介绍： Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including: • Computed tomography • Magnetic resonance imaging • Ultrasonography • Digital radiology • Interventional radiology • Radiography • Nuclear medicine Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.