Association of air pollution with frailty and sarcopenia among middle-aged and older adults: a systematic review and meta-analysis

IF 3.7 2区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Atmospheric Environment Pub Date : 2025-06-11 DOI:10.1016/j.atmosenv.2025.121350

Peng Hu , Shengtao Wei , Fei Tian , Weiyi Yang , Zhonghua Ai , Xudong Liu , Zhenhe Huang , Hualiang Lin

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引用次数: 0

Abstract

Background

The current evidence regarding the impact of air pollution on frailty and sarcopenia is inconsistent. This study aimed to synthesize evidence on the overall association of air pollution with frailty and sarcopenia risk among middle-aged and older adults.

Methods

We thoroughly searched three online databases, including Pubmed, Embase, and Web of Science, for relevant publications up to January 11, 2025. Studies evaluating the associations of indoor and outdoor air pollution with frailty and sarcopenia risk were included. Adjusted Odds Ratios (OR) with 95 % confidence intervals (CI) were computed using random-effects or fixed-effects meta-analysis. I² statistic and Q-test were used to test for heterogeneity.

Results

The study identified 38 articles. Per 10 μg/m³ increment of exposure to PM_2.5, PM_2.5-10, O₃, and NO₂ was respectively associated with 23.6 % (OR: 1.236, 95 % CI: 1.116–1.368), 17.9 % (OR: 1.179, 95 % CI: 1.126–1.234), 16.4 % (OR: 1.164, 95 % CI: 1.067–1.271), and 7.8 % (OR: 1.078, 95 % CI: 1.037–1.121) increased risk of frailty. Solid fuel use was linked to frailty measured by frailty index (OR: 1.252, 95 % CI: 1.113–1.409) and frailty measured by frailty phenotype (OR: 1.249, 95 % CI: 1.090–1.431). Each 10 μg/m³ increment of exposure to PM_2.5 (OR: 1.519, 95 % CI: 1.019–2.263) and NO₂ (OR: 1.109, 95 % CI: 1.092–1.127) increased the risk of sarcopenia.

Conclusions

Exposure to PM_2.5, PM_2.5-10, O₃, NO₂, and solid fuel increased frailty risk; PM_2.5, NO₂, and solid fuel exposure elevated the sarcopenia risk among middle-aged and older participants. These results support the implementation of sustained environmental policies to prevent frailty and sarcopenia.

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空气污染与中老年人虚弱和肌肉减少症的关系：一项系统综述和荟萃分析

目前关于空气污染对虚弱和肌肉减少症影响的证据是不一致的。本研究旨在综合空气污染与中老年人身体虚弱和肌肉减少症风险之间总体关联的证据。方法全面检索Pubmed、Embase和Web of Science三个数据库，检索截止到2025年1月11日的相关文献。评估室内和室外空气污染与虚弱和肌肉减少症风险之间关系的研究被纳入其中。采用随机效应或固定效应荟萃分析计算95%置信区间（CI）的调整优势比（OR）。采用I2统计量和q检验检验异质性。结果共鉴定出38篇文献。PM2.5、PM2.5-10、O3和NO2的暴露每增加10 μg/m3，分别与23.6% （OR: 1.236, 95% CI: 1.116-1.368）、17.9% （OR: 1.179, 95% CI: 1.126-1.234）、16.4% （OR: 1.164, 95% CI: 1.067-1.271）和7.8% （OR: 1.078, 95% CI: 1.037-1.121）的脆弱性风险增加相关。使用固体燃料与脆弱指数测量的脆弱性（OR: 1.252, 95% CI: 1.113-1.409）和脆弱表型测量的脆弱性（OR: 1.249, 95% CI: 1.090-1.431）有关。PM2.5 （OR: 1.519, 95% CI: 1.019-2.263）和NO2 （OR: 1.109, 95% CI: 1.092-1.127）暴露量每增加10 μg/m3，肌少症风险增加。结论暴露于PM2.5、PM2.5-10、O3、NO2和固体燃料环境中会增加机体脆弱风险；PM2.5、二氧化氮和固体燃料暴露会增加中老年参与者肌肉减少症的风险。这些结果支持实施可持续的环境政策，以防止虚弱和肌肉减少症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atmospheric Environment 环境科学-环境科学

CiteScore

9.40

自引率

8.00%

发文量

458

审稿时长

53 days

期刊介绍： Atmospheric Environment has an open access mirror journal Atmospheric Environment: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atmospheric Environment is the international journal for scientists in different disciplines related to atmospheric composition and its impacts. The journal publishes scientific articles with atmospheric relevance of emissions and depositions of gaseous and particulate compounds, chemical processes and physical effects in the atmosphere, as well as impacts of the changing atmospheric composition on human health, air quality, climate change, and ecosystems.