Vascular mimicry developments in non-small cell lung cancer

IF 2.2 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical and biophysical research communications Pub Date : 2025-06-11 DOI:10.1016/j.bbrc.2025.152195

Xiaoyou Zhong , Yiteng Gao , Jiajia Lv, Weifei Fan, Lin Wang

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Abstract

Non-small cell lung cancer (NSCLC) remains a prevalent and lethal malignancy worldwide, posing significant challenges in therapeutic management. The limited clinical effectiveness of conventional antiangiogenic therapies in NSCLC is mainly attributed to vasculogenic mimicry (VM), an atypical angiogenic mechanism observed in tumors. VM involves tumor cells transforming into vascular-like channels, advancing tumor progression by providing essential nutrients and oxygen. These structures, formed by tumor cells instead of endothelial cells, are resistant to traditional antiangiogenic drugs targeting vascular endothelial growth factor (VEGF) pathways, allowing tumors to evade suppression by standard antivascular treatments and significantly contributing to therapeutic resistance. Therefore, a thorough investigation of VM formation mechanisms, its regulatory pathways, and the association between VM formation mechanisms and prognosis in NSCLC has both theoretical and clinical significance for developing innovative therapeutic strategies and improving patient survival.

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非小细胞肺癌的血管拟态发展

非小细胞肺癌（NSCLC）仍然是世界范围内普遍存在的致命恶性肿瘤，在治疗管理方面提出了重大挑战。传统抗血管生成疗法在非小细胞肺癌中有限的临床疗效主要归因于血管生成模拟（VM），这是一种在肿瘤中观察到的非典型血管生成机制。VM涉及肿瘤细胞转化为血管样通道，通过提供必需的营养和氧气来促进肿瘤进展。这些结构由肿瘤细胞而不是内皮细胞形成，对靶向血管内皮生长因子（VEGF）途径的传统抗血管生成药物具有耐药性，使肿瘤能够逃避标准抗血管治疗的抑制，并显著促进了治疗耐药性。因此，深入研究NSCLC中VM形成机制及其调控途径，以及VM形成机制与预后的关系，对于制定创新治疗策略，提高患者生存率具有理论和临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical and biophysical research communications 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

1400

审稿时长

14 days

期刊介绍： Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. The development of the "Breakthroughs and Views" section brings the minireview format to the journal, and issues often contain collections of special interest manuscripts. BBRC is published weekly (52 issues/year).Research Areas now include: Biochemistry; biophysics; cell biology; developmental biology; immunology ; molecular biology; neurobiology; plant biology and proteomics