Cumulative neighborhood disadvantage and racial and geographic disparities in epigenetic aging

IF 3.6 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Ssm-Population Health Pub Date : 2025-06-10 DOI:10.1016/j.ssmph.2025.101825

Wei Xu , Christina Kamis , Joseph Clark , Amy Schultz , Michal Engelman , Kristen Malecki

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Abstract

Living in a socioeconomically disadvantaged neighborhood is associated with worse health. However, the biological pathways underpinning this association remain unclear. Using 1388 adults from Researching Epigenetics, Weathering and Residential Disadvantage (REWARD), an ancillary study to the Survey of the Health of Wisconsin (SHOW), we examined the contribution of cumulative neighborhood disadvantage across the life course to racial and geographic disparities in epigenetic markers of biological aging. Results showed that urban Black adults experienced faster epigenetic aging than urban, suburban, and rural White adults across three epigenetic aging clocks. Approximately 37 % (GrimAge), 70 % (DunedinPACE), and 100 % (PhenoAge) of the White-urban Black disparities in epigenetic age acceleration were explained by differential exposure to cumulative neighborhood disadvantage over the life course. Interactions testing differential susceptibility to neighborhood disadvantage by race were not significant. In summary, differential exposure to cumulative neighborhood disadvantage over the life course, rather than differential biological response to these exposures, shapes racial and geographic disparities in epigenetic aging.

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表观遗传衰老的累积邻里劣势、种族和地理差异

生活在社会经济条件较差的社区与较差的健康状况有关。然而，支撑这种联系的生物学途径仍不清楚。研究人员利用来自威斯康辛州健康调查（SHOW）的辅助研究——表观遗传、风化和居住劣势研究（REWARD）的1388名成年人，研究了一生中累积的邻里劣势对生物衰老表观遗传标记的种族和地理差异的贡献。结果表明，在三个表观遗传衰老时钟中，城市黑人成年人的表观遗传衰老速度快于城市、郊区和农村白人成年人。大约37% （GrimAge）、70% （DunedinPACE）和100% （PhenoAge）的白人-城市黑人在表观遗传年龄加速方面的差异可以用一生中累积的社区不利条件的不同暴露来解释。相互作用测试不同种族对邻里不利的不同易感性不显著。总之，在生命过程中，不同的暴露于累积的邻里劣势，而不是对这些暴露的不同生物反应，形成了表观遗传衰老的种族和地理差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ssm-Population Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

6.50

自引率

2.10%

发文量

298

审稿时长

101 days

期刊介绍： SSM - Population Health. The new online only, open access, peer reviewed journal in all areas relating Social Science research to population health. SSM - Population Health shares the same Editors-in Chief and general approach to manuscripts as its sister journal, Social Science & Medicine. The journal takes a broad approach to the field especially welcoming interdisciplinary papers from across the Social Sciences and allied areas. SSM - Population Health offers an alternative outlet for work which might not be considered, or is classed as ''out of scope'' elsewhere, and prioritizes fast peer review and publication to the benefit of authors and readers. The journal welcomes all types of paper from traditional primary research articles, replication studies, short communications, methodological studies, instrument validation, opinion pieces, literature reviews, etc. SSM - Population Health also offers the opportunity to publish special issues or sections to reflect current interest and research in topical or developing areas. The journal fully supports authors wanting to present their research in an innovative fashion though the use of multimedia formats.