Research progress on chitosan-based sutures: a review

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-06-09 DOI:10.1016/j.carbpol.2025.123868

Haowen Xu , Huibo Ma , Gang Guo , Cuiying Wei , Xiangyan Zhang , Mingjin Guo , Yongxin Li

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Abstract

Effective wound closure facilitates optimal tissue healing, and sutures are one of the predominant medical textiles utilized for wound closure. Chitosan, a biopolymer derived from chitin, possesses distinctive hemostatic properties, antimicrobial and anti-inflammatory activity, biocompatibility, and biodegradability, making it a prevalent choice for wound closure applications. This review provides a comprehensive summary of the current state of chitosan's application in medical sutures, focusing on recent advancements in the fabrication of chitosan-based sutures through various techniques, including wet spinning, melt spinning, electrospinning, interfacial polyelectrolyte complexes, and coating processes. Furthermore, the challenges and future trends in functionality and preparation technology of chitosan-based sutures were discussed. In conclusion, ongoing advancements in scientific research and technology are anticipated to address current limitations, positioning chitosan-based sutures as an optimal option for surgical applications and enhancing therapeutic outcomes.

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壳聚糖基缝合线的研究进展

有效的伤口闭合促进最佳组织愈合，缝合线是用于伤口闭合的主要医用纺织品之一。壳聚糖是一种从几丁质中提取的生物聚合物，具有独特的止血特性、抗菌和抗炎活性、生物相容性和生物降解性，使其成为伤口愈合应用的普遍选择。本文综述了壳聚糖在医用缝合线中的应用现状，重点介绍了壳聚糖基缝合线的制备方法，包括湿纺丝、熔融纺丝、静电纺丝、界面聚电解质配合物和涂层等。讨论了壳聚糖基缝合线在功能和制备技术方面面临的挑战和未来发展趋势。总之，科学研究和技术的不断进步有望解决目前的局限性，将壳聚糖为基础的缝合线定位为外科应用的最佳选择，并提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.