Multifunctional hydrogels: Therapeutic strategies and advances in inflammation

IF 5.8 2区化学 Q1 POLYMER SCIENCE

European Polymer Journal Pub Date : 2025-06-07 DOI:10.1016/j.eurpolymj.2025.114064

Miaomiao Liu , Tao Wang , Xueyao Wang , Weibin Ren , Yanhui Zhang , Lanjuan Li , Hongyan Diao

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引用次数: 0

Abstract

The inflammatory response is pivotal in the progression of various diseases, typically characterized by aberrant inflammation. While conventional treatments can mitigate inflammation to some degree, their therapeutic efficacy remains limited. Given the pathological complexity and clinical challenges of inflammatory diseases, there is an urgent need for novel precision modulation strategies. In recent years, hydrogels have demonstrated significant potential in inflammation management owing to their distinctive physicochemical attributes. This review systematically explores the multidimensional therapeutic strategies of hydrogel, including microenvironment-responsive targeted delivery, inflammation-regulating tissue-engineered scaffolds, immunomodulation, and smart anti-inflammatory dressings. By analyzing the pathological features of different inflammatory diseases, we elucidate the relationship between the physicochemical properties of functional hydrogels and their therapeutic mechanisms. Furthermore, we summarize recent advances in hydrogel-based inflammation therapies and discuss emerging trends in multimodal synergistic approaches. In conclusion, this review aims to advance the development of functional hydrogels for inflammation therapy by aligning their structural properties with therapeutic requirements, while addressing key challenges in delivery efficiency and long-term safety for clinical translation.

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多功能水凝胶：炎症的治疗策略和进展

炎症反应在各种疾病的进展中是关键的，通常以异常炎症为特征。虽然传统的治疗方法可以在一定程度上缓解炎症，但其治疗效果仍然有限。鉴于炎症性疾病的病理复杂性和临床挑战，迫切需要新的精确调节策略。近年来，由于其独特的物理化学特性，水凝胶在炎症治疗中表现出了巨大的潜力。本文系统地探讨了水凝胶的多维治疗策略，包括微环境响应性靶向递送、炎症调节组织工程支架、免疫调节和智能抗炎敷料。通过分析不同炎症性疾病的病理特点，阐明功能水凝胶的理化性质与治疗机制之间的关系。此外，我们总结了基于水凝胶的炎症治疗的最新进展，并讨论了多模式协同方法的新趋势。综上所述，本综述旨在通过调整其结构特性以满足治疗需求来推进炎症治疗功能水凝胶的发展，同时解决临床转化的递送效率和长期安全性方面的关键挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.