Nurbanu Sezak , Ozge Eren Korkmaz , Alper Doner , Murat Gursoy
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引用次数: 0
Abstract
Objective
During the course of chronic hepatitis B (CHB), polyneuropathy (PNP) may occur. The purpose of this study is to investigate risk factors and determine the frequency of PNP in CHB patients who have complaints such as pain, paresthesia, and numbness.
Method
The data of 350 CHB patients who presented to the neurology outpatient clinic with symptoms suggestive of PNP were retrospectively analyzed. Sociodemographic and disease-related data and nerve conduction studies (NCS) results were obtained from hospital records.
Results
PNP was found in 59 out of 350 patients. Out of these individuals, 72.9 % had axonal PNP and 27.1 % had demyelinating PNP. High hepatic activity index (HAI) score (OR = 2.74, 95 % CI: [1.63;4.72], p < 0.001), HBeAg-negative CHB (OR = 5.46, 95 % CI: [1.78;16.87], p = 0.003), male gender (OR = 7.53, 95 % CI: [3.71;15.91], p < 0.001), and advanced age (OR = 1.07, 95 % CI: [1.03;1.10], p < 0.001) were identified as independent risk factors linked to PNP. Male participants were significantly more common in the axonal PNP group (p = 0.003), while female participants predominated in the demyelinating PNP group. Disease duration was significantly longer in the demyelinating PNP group (p = 0.025). The Ishak Fibrosis Score (IFS), which reflects the severity of fibrosis, was significantly higher in the axonal group (p < 0.001).
Conclusion
Our results reveal that male gender, high HAI score, advanced age and HBeAg positivity are risk factors for PNP in CHB. Male patients who have severe liver fibrosis face a higher likelihood of developing PNP, characterized by substantial axonal damage. Conversely, female individuals with a prolonged history of CHB are susceptible to demyelinating injury. Consequently, it is advantageous to inquire about PNP problems in CHB patients during their routine examinations and, if warranted, to arrange a NCS and provide guidance for diagnosis and therapy.
期刊介绍:
This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology.
The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.