W-Alloying Induced Long-Period Stacking Ordering in Easily Delaminated (V, W)4/3Zr2/3AlC i-MAX and Excellent Antitumor Performance of (V, W)1.33C i-MXene Derivatives

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Functional Materials Pub Date : 2025-06-13 DOI:10.1002/adfm.202506151

Ni Zhao, Qing He, Xiaoxiao Fu, He Chong, Zhen Ma, Qiang Li, Hongyun Guo, Chunxia Ma, Xianjun Yu, Si Shi, Qiang Wang, Weibin Cui

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Abstract

V_4/3Zr_2/3AlC, as the only V-based i-MAX phase reported up to now, cannot be delaminated using the conventional aqueous etching strategy. In the present work, by alloying W, the structure evolves from the C2/c monoclinic one in V_4/3Zr_2/3AlC to the nanoscale co-existence of C2/c monoclinic and Cmcm orthorhombic ones in (V_0.2W_0.8)_4/3Zr_2/3AlC i-MAX with the maximum W content. Especially, at the intermediate composition of (V_0.6W_0.4)_4/3Zr_2/3AlC, the long-period stacking ordered (LPSO) structure is first observed. Feasible delamination has been realized and the resultant Zr-free (V₁₋_xW_x)_1.33C i-MXene can be obtained for x ≥ 0.6, suggesting that W-alloying is contributive to the delamination. A specific capacitance of 336.1 F g⁻¹ at the current density of 0.5 A g⁻¹ can be obtained in the (V_0.4W_0.6)_1.33C i-MXene under the extended voltage window of 1 V and highly stable performance for 10 000 charge/discharge cycles by compositing with the shell-structured activated porous carbon. Besides, biological experiments have verified that (V_0.4W_0.6)_1.33C i-MXene significantly inhibits the growth, proliferation, and migration of hepatocellular carcinoma cells by inducing apoptosis, and regulates metabolism and immune response, possessing substantial targeted antitumor potential.

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W合金化诱导易分层（V， W）4/3Zr2/3AlC i-MAX长周期有序堆积及（V， W）1.33C i-MXene衍生物优异的抗肿瘤性能

V4/3Zr2/3AlC作为迄今为止唯一报道的v基i-MAX相，不能使用常规的水相蚀刻策略进行分层。在本研究中，通过W的合金化，使得V4/3Zr2/3AlC中的C2/c单斜结构演变为（V0.2W0.8）4/3Zr2/3AlC i-MAX中C2/c单斜和Cmcm正交结构的纳米级共存，W含量最大。特别是在（V0.6W0.4）4/3Zr2/3AlC的中间组分中，首次观察到长周期有序堆积（LPSO）结构。当x≥0.6时，可以得到无zr (V1−xWx)1.33C i-MXene，表明w合金化有助于脱层。在扩展电压窗口为1 V的情况下，（V0.4W0.6）1.33C i-MXene在0.5 A g−1电流密度下的比电容可达336.1 F g−1，具有10000次充放电循环的高稳定性。此外，生物学实验证实，（V0.4W0.6）1.33C i-MXene通过诱导肝癌细胞凋亡，显著抑制肝癌细胞的生长、增殖和迁移，调节代谢和免疫应答，具有较强的靶向抗肿瘤潜力。

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.