The NLRP3 inflammasome and its role in acute myeloid leukemia onset and development

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-06-09 DOI:10.1016/j.bbcan.2025.189371

Brunno Gilberto Santos de Macedo , Manuela Albuquerque de Melo , Diego Antonio Pereira-Martins , João Agostinho Machado-Neto , Fabiola Traina

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引用次数: 0

Abstract

The tumor microenvironment plays an important role in cancer onset and progression. Its significance has been increasingly addressed in myeloid neoplasms. Such a shift marks a departure from the usual tumor-centered approach to a more comprehensive and integrated understanding of the interplay between myeloid tumors and their surroundings.

On this note, we aimed to summarize, in this review, an up-to-date take on how a pro-inflammatory milieu influences clonal selection of genetically altered hematopoietic stem cells towards myeloid malignancies at the expense of their healthy counterpart; the role of NLRP3 inflammasome, a major component of the innate immunity and source of interleukin-1β, over acute myeloid leukemia development and performance; and, alongside post-translational modifications, how autophagy represents a major NLRP3 inflammasome regulator.

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NLRP3炎性小体及其在急性髓性白血病发生和发展中的作用。

肿瘤微环境在肿瘤的发生和发展中起着重要的作用。它在髓系肿瘤中的重要性已日益得到重视。这种转变标志着从通常的以肿瘤为中心的方法转向对髓系肿瘤及其周围环境之间相互作用的更全面和综合的理解。在这一点上，我们的目的是总结，在这篇综述中，关于促炎环境如何影响基因改变的造血干细胞克隆选择，以牺牲健康的骨髓恶性肿瘤为代价的最新研究；NLRP3炎性小体（先天免疫的主要组成部分和白细胞介素-1β的来源）在急性髓系白血病的发展和表现中的作用；以及，除了翻译后修饰，自噬如何代表NLRP3炎症小体的主要调节因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.