Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study.

IF 4.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Report Pub Date : 2025-06-11 eCollection Date: 2025-01-01 DOI:10.1093/gastro/goaf042

Xinyang Liu, Ruilang Lin, Xinyue Li, Mengjiang He, Yanbo Liu, Jianwei Hu, Weifeng Chen, Quanlin Li, Yongfu Yu, Pinghong Zhou

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引用次数: 0

Abstract

Background: We aimed to investigate associations between three perinatal early-life factors and the risk of irritable bowel syndrome (IBS) in middle-aged and elderly people by using data from UK Biobank.

Methods: This is a population-based cohort study. Participants who had available data on early-life factors-namely maternal smoking around birth, being breastfed as a baby, and being one of a multiple birth and without IBS at the time of recruitment in UK Biobank-were included.

Results: Among a total of 334,586 subjects, 93,908 (28.07%) were exposed to maternal smoking around birth, 243,778 (72.86%) were breastfed as a baby, and 7,551 (2.26%) were part of a multiple birth. During a median follow-up of 13.58 years, 7,254 participants developed IBS, at a median age of 63 years. The hazard ratios of IBS were 1.22 [95% confidence interval (CI), 1.16-1.28, P < 0.001], 0.92 (95% CI, 0.87-0.97, P = 0.002), and 1.22 (95% CI, 1.06-1.40, P = 0.006) for maternal smoking, breastfeeding, and multiple birth, respectively. The joint effect of any two of these three factors was related to added influence instead of interaction between them. The effect of maternal smoking on IBS was modified by age, while the modifiers of the effect of being breastfed as a baby on IBS were the age and sex of the offspring.

Conclusions: Participants exposed to maternal smoking around birth and being one of a multiple birth had a higher risk of IBS in middle-aged and elderly stages, while being breastfed as a baby had a protective effect against IBS. Future efforts should be made to validate the results.

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在老年人中，母亲吸烟、母乳喂养和多胞胎与肠易激综合征的关系：英国生物银行队列研究

背景：我们旨在通过英国生物银行的数据，调查三种围产期早期生活因素与中老年人肠易激综合征（IBS）风险之间的关系。方法：这是一项基于人群的队列研究。在英国生物银行招募时，有早期生活因素数据的参与者——即母亲在分娩时吸烟，婴儿时母乳喂养，多胞胎之一，没有肠易激综合征——被包括在内。结果：在334,586名受试者中，93,908名（28.07%）在分娩前后暴露于母亲吸烟，243,778名（72.86%）在婴儿时期接受母乳喂养，7,551名（2.26%）是多胎分娩的一部分。在平均13.58年的随访期间，7254名参与者发展为肠易激综合征，平均年龄为63岁。母亲吸烟、母乳喂养和多胞胎的IBS风险比分别为1.22（95%可信区间，1.16 ~ 1.28,P 0.001）、0.92 （95% CI, 0.87 ~ 0.97, P = 0.002）和1.22 （95% CI, 1.06 ~ 1.40, P = 0.006）。这三个因素中的任何两个的联合效应都与附加影响有关，而不是它们之间的相互作用。母亲吸烟对肠易激综合征的影响受年龄的影响，而婴儿时期母乳喂养对肠易激综合征影响的调节因素是后代的年龄和性别。结论：在分娩前后暴露于母亲吸烟和多胞胎的参与者在中老年阶段患IBS的风险更高，而在婴儿时期接受母乳喂养对IBS有保护作用。今后应努力验证这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology Report Medicine-Gastroenterology

CiteScore

4.60

自引率

2.80%

发文量

审稿时长

8 weeks

期刊介绍： Gastroenterology Report is an international fully open access (OA) online only journal, covering all areas related to gastrointestinal sciences, including studies of the alimentary tract, liver, biliary, pancreas, enteral nutrition and related fields. The journal aims to publish high quality research articles on both basic and clinical gastroenterology, authoritative reviews that bring together new advances in the field, as well as commentaries and highlight pieces that provide expert analysis of topical issues.