Diagnosis and treatment of metachronous multiple primary carcinoma: A case report and review of literature.

IF 2.6 Q3 ONCOLOGY

World journal of clinical oncology Pub Date : 2025-05-24 DOI:10.5306/wjco.v16.i5.105444

Min Luo, Rui-Na Liu, Zhen-Mei He, Qian-Fu Liang, Feng-Ling Huang

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引用次数: 0

Abstract

Background: Multiple primary carcinoma (MPC) refers to two or more types of primary malignant tumors occurring simultaneously or sequentially in the same patient. Breast cancer is one of the most common malignant tumors affecting women. On the other hand, diffuse large B-cell lymphoma (DLBCL) is the most frequent form of non-Hodgkin's lymphoma (NHL). In clinical practice, the simultaneous existence of metachronous primary breast cancer and lymphoma is rare. In this case, we highlight the significance of multidisciplinary management and advanced imaging techniques in the early identification and treatment of MPC cases.

Case summary: In this study, we report a case of a 40-year-old female who was diagnosed with invasive ductal carcinoma of the breast (T3N1M0 stage IIIA LuminalB type) as the first primary cancer and DLBCL (stage IIIA) as the second primary cancer. The patient underwent the modified radical mastectomy for left breast cancer and received Rituximab, cyclophospha-mide, hydroxydaunorubicin, Oncovin (vincristine) and prednisolone regimen chemotherapy treatment for DLBCL. As of now, the patient is in stable condition. The successful diagnosis of the present patient highlights the need for multidisciplinary management and adoption of advanced imaging techniques to identify the second primary cancer, especially NHL.

Conclusion: Accurate diagnosis and management of metachronous MPC requires an interdisciplinary team and selection of an appropriate treatment plan.

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异时性多发原发癌的诊断与治疗：1例报告及文献复习。

背景：多原发癌（Multiple primary carcinoma， MPC）是指同一患者同时或先后发生的两种或两种以上的原发性恶性肿瘤。乳腺癌是影响女性的最常见的恶性肿瘤之一。另一方面，弥漫性大b细胞淋巴瘤（DLBCL）是最常见的非霍奇金淋巴瘤（NHL）。在临床实践中，异时性原发性乳腺癌和淋巴瘤同时存在是罕见的。在这种情况下，我们强调多学科管理和先进的成像技术在早期识别和治疗MPC病例中的重要性。病例总结：本研究报告一例40岁女性，诊断为浸润性乳腺导管癌（T3N1M0 IIIA期LuminalB型）为第一原发癌，DLBCL （IIIA期）为第二原发癌。患者接受左乳腺癌改良根治性乳房切除术，并接受利妥昔单抗、环磷酰胺、羟基柔红霉素、Oncovin（长春新碱）和强的松龙方案化疗治疗DLBCL。截至目前，患者情况稳定。本例患者的成功诊断表明需要多学科管理和采用先进的成像技术来识别第二原发癌症，特别是非霍奇金淋巴瘤。结论：对异时性MPC的准确诊断和治疗需要一个跨学科的团队，并选择合适的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of clinical oncology ONCOLOGY-

自引率

0.00%

发文量

585

期刊介绍： The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.