The protective role of Calotropis procera Linn against cisplatin-induced oxidative stress, insight into antioxidant effects.

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Sardar Ali, Saima Nawaz, Shakir Ullah, Zainab Irshad, Niaz Ali, Ahad Nawaz, Muhammad Riaz, Najm Ur Rahman
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Abstract

It has been hypothesized that inflammation and oxidative stress have a potential role in neurodegeneration. Cisplatin is a commonly used in different types of cancers but it is notorious for oxidative stress which leads to neurodegeneration. Therefore, the current study focused on the antioxidant effect of Calotropis procera during cisplatin treatment. The methanolic extract of C. procera was extracted using rotary evaporator. Memory impairment was evaluated by using Y-Maze and Morris water model. The antioxidant effect of C. procera extract was measured by assessing oxidative stress markers such as lipid peroxidation (LPO), reactive oxygen species (ROS), glutathione (GSH), and catalase (CAT) in the experimental groups. It has been found that C. procera extract showed a significant (p<0.05) effect on preventing memory dysfunction compared to a positive control (cisplatin). The effect of C. procera extract was observed in a dose-dependent manner. Similarly, the increase (p<0.05) in the level of oxidative stress marker was high compared to the positive control group in a dose-dependent manner. While the decrease in the level of malondialdehyde (MDA) was found in the C. procera extract treated groups dose-dependently. C. procera significantly reduces cisplatin-induced oxidative stress by restoring the level of antioxidant enzymes and reducing MDA levels. The therapeutic benefits are significant at a dose of 400 mg/kg.

原花椒对顺铂诱导的氧化应激的保护作用,洞察抗氧化作用。
据推测,炎症和氧化应激在神经变性中有潜在的作用。顺铂通常用于不同类型的癌症,但它因氧化应激导致神经退行性变而臭名昭著。因此,目前的研究主要集中在顺铂治疗过程中的抗氧化作用。采用旋转式蒸发器提取青果仁甲醇提取物。采用Y-Maze和Morris水模型评价记忆损伤。采用脂质过氧化(LPO)、活性氧(ROS)、谷胱甘肽(GSH)、过氧化氢酶(CAT)等氧化应激指标测定试验组procera提取物的抗氧化作用。结果表明,原果脯提取物具有显著的(p
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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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