Efficacy of Intravenous Methylprednisolone Pulses in Children With Postinfectious Bronchiolitis Obliterans.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-06-01 DOI:10.1002/ppul.71150

Souad Ghattas, David Drummond, Alice Hadchouel

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引用次数: 0

Abstract

Objective: To assess the efficacy of intravenous methylprednisolone pulses in children with postinfectious bronchiolitis obliterans (PIBO).

Study design/methods: This French monocentric retrospective study included 31 patients with PIBO. Respiratory symptoms, occurrence of exacerbations and hospitalizations up to 4 years, and the results of lung function tests were compared between patients who received methylprednisolone pulses (n = 6) and those who did not (n = 25). A similar analysis was performed in the subgroup of the severest patients at diagnosis (five and six patients per group respectively).

Results: During their inaugural episode, patients in the treatment group were hospitalized longer (p = 0.005), more frequently in ICU (p = 0.013) and had longer oxygen needs than in the control group (p = 0.005). During their course, more patients in the treatment group required at least one nonscheduled hospitalization at 6 months of evolution than in the control group (p = 0.04). Regarding lung function tests, no significant difference was observed between the control and treatments groups. Comparing the severest patients at diagnosis in each group showed no significant difference in clinical nor functional evolution.

Conclusion: In a retrospective monocentric cohort, intravenous methylprednisolone pulses were used in severe cases of PIBO. This treatment had no effect of the subsequent evolution of these patients as compared to not treated patients.

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静脉注射甲基强的松龙脉冲治疗小儿感染后闭塞性细支气管炎的疗效。

目的：评价甲基强的松龙静脉注射治疗小儿感染后闭塞性细支气管炎（PIBO）的疗效。研究设计/方法：这项法国单中心回顾性研究包括31例PIBO患者。比较接受甲基强的松龙脉冲治疗的患者（n = 6）和未接受甲基强的松龙脉冲治疗的患者（n = 25）之间的呼吸系统症状、恶化发生率和住院时间长达4年的情况以及肺功能检查结果。在诊断时最严重的患者亚组中进行了类似的分析（每组分别有5名和6名患者）。结果：与对照组相比，治疗组患者首次发作时住院时间更长（p = 0.005），入住ICU的频率更高（p = 0.013），需氧量更长（p = 0.005）。在治疗过程中，治疗组在6个月时至少需要一次非计划住院治疗的患者多于对照组（p = 0.04）。在肺功能测试方面，对照组和治疗组之间无显著差异。比较诊断时的重症患者，各组在临床和功能进化上均无显著差异。结论：在回顾性单中心队列中，静脉注射甲基强的松龙脉冲用于严重PIBO病例。与未接受治疗的患者相比，这种治疗对这些患者的后续演变没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.