A prospective randomized trial comparing dephereline and busereline for ovulation induction in heat-stressed lactating dairy cows.

IF 2.2 4区生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Journal of Reproduction and Development Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI:10.1262/jrd.2025-023

Fernando López-Gatius

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Abstract

Climate change is causing heat stress (HS) in dairy cattle. This study aimed to compare the clinical efficacy of two GnRH synthetic analogs, dephereline and busereline, as ovulation inducers under HS conditions. The study population comprised 1,000 lactating dairy cows showing signs of spontaneous estrus which were assigned to the groups: DEPH (489 cows receiving 100 µg of dephereline) and BUS (511 cows receiving 10 µg of busereline) at the time of insemination. Cows were included only once in the study. Treatment with busereline increased the risk of multiple ovulations and twin pregnancies, with an odds ratio (OR) of 1.6, and twin pregnancies, with an OR of 2.8, when compared with dephereline. The likelihood of pregnancy in multiple-ovulating cows was significantly higher in the DEPH group than the BUS group. Collectively, our results comparing two ovulation inducers showed that dephereline treatment may improve the fertility of lactating dairy cows under HS conditions.

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一项比较去phereline和busereline对热应激泌乳奶牛促排卵作用的前瞻性随机试验。

气候变化正在引起奶牛的热应激（HS）。本研究旨在比较两种GnRH合成类似物dephereline和busereline在HS条件下作为促排卵剂的临床疗效。研究人群包括1000头有自发发情迹象的泌乳奶牛，在授精时被分为deep组（489头奶牛接受100微克的去phereline）和BUS组（511头奶牛接受10微克的去phereline）。奶牛只被纳入了一次研究。与去酚林相比，布索林治疗增加了多胎排卵和双胎妊娠的风险，比值比（OR）为1.6，双胎妊娠的OR为2.8。多次排卵奶牛的妊娠可能性在deep组显著高于BUS组。综上所述，我们对两种排卵诱导剂的比较结果表明，在HS条件下，去phereline处理可以提高泌乳奶牛的生育能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Reproduction and Development 生物-奶制品与动物科学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

2 months

期刊介绍： Journal of Reproduction and Development (JRD) is the official journal of the Society for Reproduction and Development, published bimonthly, and welcomes original articles. JRD provides free full-text access of all the published articles on the web. The functions of the journal are managed by Editorial Board Members, such as the Editor-in-Chief, Co-Editor-inChief, Managing Editors and Editors. All manuscripts are peer-reviewed critically by two or more reviewers. Acceptance is based on scientific content and presentation of the materials. The Editors select reviewers and correspond with authors. Final decisions about acceptance or rejection of manuscripts are made by the Editor-in-Chief and Co-Editor-in-Chief.