The risk factors for asthma in adolescents: a systematic review and meta-analysis.

IF 1.3 4区医学 Q3 ALLERGY

Journal of Asthma Pub Date : 2025-10-01 Epub Date: 2025-06-19 DOI:10.1080/02770903.2025.2519106

Hoileong Lee, Linyan Tang, Xin Wen

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引用次数: 0

Abstract

Objective: To identify risk factors for asthma in adolescents and provide a reference for disease management.

Methods: PubMed, Embase, Web of science and Cochrane library were searched from inception to November 1st, 2024. The quality was evaluated by using the Agency for Healthcare Research and Quality and the New Ottawa Scal. The range of scores for inclusion in the study was 7-9. Heterogeneous results were pooled using a random-effects model and reported as odds ratio (OR).

Results: Fifteen studies comprising 73,314 participants were included. The results of forest map showed that a total of 12 risk factors were associated with asthma in adolescents. Previous hypersensitivity reaction (OR 2.87 [95% CI 2.50-3.31]; p < 0.001), history of family hypersensitivity reaction (OR 2.35 [95% CI 1.93-2.86]; p < 0.001), history of family asthma (OR 2.48 [95% CI 1.97-3.12]; p < 0.001), active smoking (OR 1.47 [95% CI 1.28, 1.69]; p < 0.001), exposure to secondhand smoke (OR 1.27 [95% CI 1.20-1.34]; p < 0.001), domestic animals (OR 1.21 [95% CI 1.13-1.29]; p < 0.001), outdoor pollution (OR 1.27 [95% CI 1.15, 1.41]; p < 0.001), and biofuel (OR 1.10 [95% CI 1.02-1.19]; p < 0.001), and obese/overweight (OR 1.26 [95% CI 1.13-1.40]; p < 0.001), private school (OR 1.82 [95% CI 1.52-2.18]; p < 0.001), and female (OR 1.21 [95% CI 1.11-1.32]; p < 0.001) were found to be correlated.

Conclusions: This study may provide a reference to inform the development of preventive strategies and management of adolescent asthma.

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青少年哮喘的危险因素：系统回顾和荟萃分析。

目的：了解青少年哮喘的危险因素，为疾病管理提供参考。数据来源：对PubMed， Embase， Web of Science和Cochrane Library数据库进行全面的文献检索，从开始到2024年11月1日。研究选择：本研究使用卫生保健研究与质量机构和纽卡斯尔-渥太华量表进行质量评估。纳入研究的得分范围是7到9分。异质结果采用随机效应模型汇总，并以比值比（OR）报告。结果：纳入15项研究，73,314名受试者。森林地图结果显示，共有12种危险因素与青少年哮喘相关。既往超敏反应(OR 2.87 [95% CI 2.50-3.31]；p< 0.001)、家族超敏反应史(OR 2.35 [95% CI 1.93-2.86]；p< 0.001)、家族哮喘史(OR 2.48 [95% CI 1.97-3.12]；p< 0.001)，主动吸烟(OR 1.47 [95% CI 1.28, 1.69]；p< 0.001)，暴露于二手烟(OR 1.27 [95% CI 1.20-1.34]；p< 0.001)，家畜(OR 1.21 [95% CI 1.13-1.29]；p< 0.001)，室外污染(OR 1.27 [95% CI 1.15, 1.41]；p< 0.001)和生物燃料(OR 1.10 [95% CI 1.02-1.19]；p< 0.001)，肥胖/超重(OR 1.26 [95% CI 1.13-1.40]；p< 0.001)，私立学校(OR 1.82 [95% CI 1.52-2.18]；p< 0.001)，女性(OR 1.21 [95% CI 1.11- 1.32]；P < 0.001)存在相关性。结论：本研究可为制定青少年哮喘的防治策略提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asthma 医学-过敏

CiteScore

4.00

自引率

5.30%

发文量

158

审稿时长

3-8 weeks

期刊介绍： Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.