Importance of potential prothrombotic state markers in Behçet's disease and correlation with vascular ultrasound.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2025-06-12 DOI:10.1007/s11845-025-03972-x

Hazan Karadeniz, Tunjay Mammadov, Mahi Nur Cerit, Rıza Can Kardas, Aslıhan Avanoglu Guler, Derya Yıldırım, Ibrahim Vasi, Hatice Pasaoglu, Abdulsamet Erden, Hamit Kucuk, Berna Goker, Mehmet Akif Ozturk, Abdurrahman Tufan

{"title":"Importance of potential prothrombotic state markers in Behçet's disease and correlation with vascular ultrasound.","authors":"Hazan Karadeniz, Tunjay Mammadov, Mahi Nur Cerit, Rıza Can Kardas, Aslıhan Avanoglu Guler, Derya Yıldırım, Ibrahim Vasi, Hatice Pasaoglu, Abdulsamet Erden, Hamit Kucuk, Berna Goker, Mehmet Akif Ozturk, Abdurrahman Tufan","doi":"10.1007/s11845-025-03972-x","DOIUrl":null,"url":null,"abstract":"Objective: The study aims to evaluate the relationship between prothrombotic soluble serum levels of P-selectin, citrullinated histone H3 (CitH3), and growth differentiation factor-15 (GDF-15) and the thickness measurements of the carotid artery, femoral, portal, and jugular veins in patients with Behçet's disease (BD).Methods: Fifty-six BD patients who met the International Study Group criteria and 19 healthy control subjects were enrolled. We compared the groups' differences in B-mode ultrasound findings and biochemical prothrombotic markers. Logistic regression was used to analyze independent factors influencing thrombosis, and a receiver operating characteristic curve was plotted.Results: A total of 34 non-vascular and 22 vascular BD patients (mean age 41.5 ± 11.8 years, 38 (67.9%) male) were included in the study. No significant differences were observed between patients and healthy controls (HCs) in terms of sex, age, and body mass index. BD patients had elevated serum levels of P-selectin, CitH3, and GDF-15 compared to HCs (p < 0.05). CitH3 and GDF-15 levels were significantly higher in BD patients with vascular involvement than those without vascular disease (p < 0.05). The GDF-15 level in vascular BD patients showed a significant correlation with femoral vein thickness.Conclusion: GDF-15 and CitH3 are potential biomarkers that show vascular involvement and thrombosis in BD.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Irish Journal of Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11845-025-03972-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The study aims to evaluate the relationship between prothrombotic soluble serum levels of P-selectin, citrullinated histone H3 (CitH3), and growth differentiation factor-15 (GDF-15) and the thickness measurements of the carotid artery, femoral, portal, and jugular veins in patients with Behçet's disease (BD).

Methods: Fifty-six BD patients who met the International Study Group criteria and 19 healthy control subjects were enrolled. We compared the groups' differences in B-mode ultrasound findings and biochemical prothrombotic markers. Logistic regression was used to analyze independent factors influencing thrombosis, and a receiver operating characteristic curve was plotted.

Results: A total of 34 non-vascular and 22 vascular BD patients (mean age 41.5 ± 11.8 years, 38 (67.9%) male) were included in the study. No significant differences were observed between patients and healthy controls (HCs) in terms of sex, age, and body mass index. BD patients had elevated serum levels of P-selectin, CitH3, and GDF-15 compared to HCs (p < 0.05). CitH3 and GDF-15 levels were significantly higher in BD patients with vascular involvement than those without vascular disease (p < 0.05). The GDF-15 level in vascular BD patients showed a significant correlation with femoral vein thickness.

Conclusion: GDF-15 and CitH3 are potential biomarkers that show vascular involvement and thrombosis in BD.

查看原文本刊更多论文

潜在血栓形成状态标志物在behaperet病中的重要性及其与血管超声的相关性。

目的：本研究旨在评价behet病（BD）患者血栓前溶性血清p -选择素、瓜氨酸组蛋白H3 （CitH3）和生长分化因子-15 （GDF-15）水平与颈动脉、股静脉、门静脉和颈静脉厚度的关系。方法：入选56例符合国际研究组标准的BD患者和19例健康对照。我们比较两组在b超表现和生化血栓前标志物方面的差异。采用Logistic回归分析影响血栓形成的独立因素，绘制受试者工作特征曲线。结果：共纳入非血管性BD患者34例，血管性BD患者22例，平均年龄41.5±11.8岁，男性38例（67.9%）。在性别、年龄和体重指数方面，患者和健康对照（hc）之间没有观察到显著差异。与hcc患者相比，BD患者血清p -选择素、CitH3和GDF-15水平升高（p < 0.05）。伴有血管病变的BD患者的CitH3和GDF-15水平明显高于无血管病变的患者（p < 0.05）。血管性BD患者GDF-15水平与股静脉厚度有显著相关性。结论：GDF-15和CitH3是BD患者血管受损伤和血栓形成的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.